In vivo Research Associate, Oncology

Pattern Biosciences; South San Francisco (CA); On-site; USD 120,000 - 170,000; Full time

Job summary

Pattern Bio in South San Francisco seeks an experienced in vivo scientist to advance our AAV-based cancer therapies. You will design and execute preclinical studies with a focus on rigor and regulatory compliance within a cross-disciplinary team.

You will plan and perform in vivo murine studies, including surgeries, dosing, tumor monitoring, tissue processing and data analysis, contributing to the oncology pipeline at Pattern Bio.

Qualifications

• MSc in life sciences.
• At least 3 years of hands-on experience with murine oncology models.
• Hands-on experience with complex rodent procedures including thoracic or abdominal surgery, suturing and wound closure, and tail vein dosing.
• Experience in necropsy, tissue handling and processing, tumor cell and splenocyte isolation, and flow cytometry.
• Detail-oriented with strong organizational and record-keeping skills.
• Excellent communication and ability to collaborate in a cross-functional team.
• Experience in a GLP or regulatory-compliant environment is a plus.

Responsibilities

• Plan and execute in vivo studies in collaboration with discovery and data scientists.
• Perform various in vivo procedures in mice: dosing via IV, IP and SC, blood sampling, and complex surgeries to establish orthotopic tumor models.
• Monitor tumor volume by in vivo imaging or caliper measurement and conduct necropsy and tissue processing.
• Perform mammalian cell culture and QC for in vivo experiments.
• Generate, document and analyze in vivo study data in accordance with protocols, SOPs and regulations.
• Interface with external laboratories and partners.

Skills

Murine oncology models

Complex rodent procedures

Suturing & wound closure

Tail vein dosing

Necropsy & tissue handling

Flow cytometry

Documentation & record-keeping

Cross-functional collaboration

Education

MSc in life sciences

Tools

MACS

FACS

Job description

You will perform in vivo studies of our AAV-based cancer therapeutic candidates to advance our oncology pipeline and technology platform. You will contribute to the design of the preclinical studies and their execution, ensuring high level of scientific rigor and compliance with relevant regulations. This is an ideal position for a candidate with a strong background in vivo experiments who thrives in a team-oriented, cross-disciplinary, and collaborative environment.

Primary Responsibilities

• Plan and execute in vivo studies in collaboration with discovery and data scientists
• Perform various in vivo procedures in mice: dosing via IV, IP and SC, blood sampling, and complex surgeries to establish orthotopic tumor models via abdominal surgery
• Conduct routine animal health monitoring and recording and monitor tumor volume by in vivo imaging or caliper measurement
• Perform necropsy, biological sample processing, tissue dissociation and cell sorting via MACS or FACS, and downstream analysis
• Conduct mammalian cell culture and QC for in vivo experiments
• Generate, document and analyze in vivo study data in accordance with study protocols, SOPs, and regulatory guidelines
• Interface with external laboratories and partners

Required Skills & Qualifications

• MSc in life sciences.
• At least 3 years of hands-on experience working with murine oncology models in an academic or industry setting.
• Strong hands-on experience with complex rodent procedures, such as thoracic or abdominal surgery, suturing and wound closure, and tail vein dosing
• Experience in necropsy, tissue handling and processing, tumor cell and splenocyte isolation, and flow cytometry
• Detail-oriented with strong organizational and record-keeping skills
• Excellent communication skills and ability to collaborate effectively in a cross-functional team.
• Experience working in a GLP or regulatory-compliant environment is a plus.

At Pattern Bio, we design biological circuits at the intersection of synthetic biology and AI for cell-specific targeting of cancer tissue. By integrating data-driven design into every step—from DNA constructs to AAV-based delivery systems—we are building precise, rationally engineered, curative therapies. Our cohesive and driven team in South San Francisco is dedicated to curing cancer and saving lives.