Scientist - In Vitro Global Safety Pharmacology

Net2Source (N2S); Groton (CT); On-site; USD 95,000 - 120,000; Full time

Job summary

Net2Source (N2S) seeks a Scientist – In Vitro Global Safety Pharmacology in Groton, CT to support drug discovery by conducting in vitro experiments that assess off-target pharmacology of novel compounds through cellular and biochemical assays.

The role involves independent and team-based work, data analysis with Excel/GraphPad Prism, and detailed documentation. Preferred background includes receptor pharmacology principles and relevant assay platforms.

Qualifications

• Bachelor's degree in Pharmacology or related field with 5+ years of laboratory experience.
• Experience running cell/enzyme-based assays in medium to high throughput environments.
• Cell culture experience and ability to work independently in a fast-paced setting.
• Proficiency with data analysis tools (Excel, GraphPad Prism) and presentations.

Responsibilities

• Design, execute, and interpret in vitro experiments for safety pharmacology screens.
• Perform aseptic cell culture for multiple cell lines and assist biochemical/bi-cell assays.
• Maintain detailed records and prepare study summaries/reports.
• Collaborate with stakeholders and use software tools to document data and findings.

Skills

Analytical thinking

Detail-oriented

Team collaboration

Education

Bachelor's degree in Pharmacology or related field

Tools

Molecular Devices FLIPR

Revvity Envision/Nexus

PerkinElmer Micro beta 2

Revity Signals Electronic Notebook

Job description

Job title: Scientist - In Vitro Global Safety Pharmacology

Location – Groton CT

Duration: 12+ Months

Role Description:

This position will be responsible for supporting drug discovery by performing in vitro experiments to assess the off-target pharmacology of novel compounds using both cellular and biochemical assays.

Responsibilities:

Work independently and as part of a team to help design, execute, analyze / interpret data generated from experiments from biochemical and in vitro cell-based assays.

Specific duties to include:

• Apply scientific knowledge in running early in-vitro safety screening assays (384 well plate based; medium throughput) using a range of in vitro cell based, enzyme assays and transporter assays.
• Support screening efforts by performing aseptic cell culture work for multiple cell lines.
• Keep detailed experimental records and prepare study summaries and technical reports.
• Have a working knowledge of analysis tools such as Excel, GraphPad Prism, and PowerPoint for experimental documentation and data analysis/presentations.
• Contribute to building an innovative culture that embraces scientific excellence, urgency, partnerships with key stakeholders, continuous learning and improvement, increasing technical skill base and in vitro expertise.

Basic Qualifications:

• Bachelor's degree plus 5 years pertinent laboratory experience in Pharmacology (or related field).
• Previous experience running cell/enzyme-based assay platforms in a medium to high throughput environment is required. Experience using plate-based instrumentation (liquid handling, fluorescent plate readers, plate-based scintillation counters)
• Cell culture experience
• Eagerness to learn new laboratory techniques
• Ability to work in fast paced environment and meet deadlines.
• Strong organizational, interpersonal and communication skills as well as ability to perform tasks with minimal supervision. Team player attitude is a must.
• Excellent time-management skills and ability to follow pre-established experimental designs and troubleshoot problems in an independent manner.

Preferred Qualifications:

• Working knowledge of receptor pharmacology principles
• Experience with Molecular Devices FLIPR, Revvity Envision and Envision Nexus, Perkin Elmer Microbeta2 platforms
• Experience using Revity Signals Electronic Notebook