Scientist II, Radiopharmacology

Champions Oncology, Inc.; Rockville (MD); Hybrid; USD 90,000 - 110,000; Full time

Job summary

Champions Oncology, Inc. in Rockville, MD seeks a Scientist II, Radiopharmacology to design and execute radiolabeling reactions with isotopes such as Lu-177, Ac-225, and Zr-89.

The role includes developing protocols, performing QC, and supporting in vivo studies to advance radiopharmaceutical programs. You will train junior staff, maintain rigorous documentation, and collaborate with cross-functional teams to ensure compliant, high-quality radiochemical work and data interpretation in a

Qualifications

• Expertise in radiochemistry, radiopharmacology, radiobiology, molecular imaging, and the handling of diagnostic and therapeutic radionuclides.
• Experience with radiolabeling chemistry, bifunctional chelators, conjugation chemistry, and radiopharmaceutical formulation.
• Experience with in vivo studies using radiolabeled compounds.

Responsibilities

• Design and execute radiolabeling reactions with isotopes (Lu-177, Ac-225, In-111, Zr-89, At-211, I-131, Pb-212).
• Develop, optimize, and troubleshoot radiochemical synthesis protocols for diagnostic and therapeutic applications.
• Perform QC and stability testing of radiolabeled compounds using analytical methods.

Skills

Radiochemistry

Radiopharmacology

Radiobiology

Molecular imaging

Radionuclide handling

Education

PhD in radiochemistry

Tools

TLC

Radio-TLC

HPLC

Radio-HPLC

Job description

# Scientist II, RadiopharmacologyHot JobRockville MD - Rockville, MD 20850## OverviewSalary Range$90,000.00 - $110,000.00 Salary/yearLevelExperiencedPosition TypeFull TimeEducation LevelPhDTravel PercentageNoneCategoryBiotech## Description**Position Title:** Scientist II, Radiopharmacology**Reporting Location:** Rockville, MD**Reports To:** Head of Radiopharmacology**DUTIES, RESPONSIBILITIES:*** Design and execute radiolabeling reactions using a range of isotopes, including Lu-177, Ac-225, In-111, Zr-89, At-211, I-131, and Pb-212.* Perform conjugation reactions between bifunctional chelators and peptides, proteins, antibodies, or other biological molecules.* Develop, optimize, and troubleshoot radiochemical synthesis and radiolabeling protocols for both diagnostic and therapeutic applications.* Conduct quality control and stability testing of radiolabeled compounds using appropriate analytical methods.* Analyze experimental data, interpret results, and communicate findings to cross-functional teams.* Support the design, execution, analysis, and interpretation of in vivo studies involving radiolabeled compounds.* Develop, write, review, and maintain technical documents, including methods, SOPs, protocols, work instructions, and other documentation, in adherence to the Champions quality control system.* Prepare, review, and ensure compliance of study protocols, technical reports, experimental procedures, and study-related documentation.* Train and mentor junior staff in radiochemistry techniques, radiopharmacology procedures, radiation safety, quality control, and the safe handling of radioactive materials.* Maintain accurate, complete, and traceable laboratory records, including experimental procedures, calculations, analytical results, and instrument records.* Stay current with advancements in radiochemistry, radiopharmacology, molecular imaging, targeted radionuclide therapy, and nuclear medicine.* Assist in the evaluation, validation, implementation, and routine use of new laboratory equipment, automation systems, analytical tools, and technologies.* Collaborate with internal scientific teams, project managers, laboratory operations, and other cross-functional groups to support successful study execution.* Assist with troubleshooting radiochemistry, formulation, analytical, and study-related issues as needed.* Support laboratory organization, radioactive material management, and appropriate handling and disposal of radioactive waste in accordance with established procedures.* Perform additional duties as assigned, either verbally or in writing, at any time.## Qualifications**KNOWLEDGE, SKILLS, AND ABILITIES:*** Expertise in radiochemistry, radiopharmacology, radiobiology, molecular imaging, and the handling of diagnostic and therapeutic radionuclides.* Expertise in chromatographic and analytical techniques, including thin-layer chromatography (TLC), radio-TLC, column chromatography, high-performance liquid chromatography (HPLC), and radio-HPLC.* Strong knowledge of radiolabeling chemistry, bifunctional chelators, conjugation chemistry, and radiopharmaceutical formulation.* Expertise in conducting in vivo studies using radiolabeled compounds.* Experience with the analysis and interpretation of in vivo data from radiolabeled compounds, including biodistribution, pharmacokinetic, imaging, and dosimetry data.* Ability to troubleshoot radiochemical reactions, analytical methods, instrumentation, and experimental procedures.* Knowledge of radiation safety principles and appropriate handling, storage, use, and disposal of radioactive materials.* Ability to work independently as well as collaboratively within multidisciplinary and cross-functional teams.* Strong scientific writing, data interpretation, problem-solving, organizational, and communication skills.**EDUCATION AND EXPERIENCE:*** PhD in a relevant scientific field, such as radiochemistry, chemistry, biochemistry, pharmaceutical sciences, radiopharmaceutical sciences, or related discipline.* Demonstrated expertise in radiochemistry, radiopharmacology, radiobiology, molecular imaging, and therapeutic radionuclide applications.* Experience with diagnostic and therapeutic radioisotopes and the development of radiolabeled compounds.* Knowledge and practical experience with radiochromatographic techniques, including radio-TLC and radio-HPLC.* Experience with the analysis and interpretation of in vivo data generated from radioconjugates or radiopharmaceuticals.* Experience with preclinical biodistribution, pharmacokinetic, imaging, dosimetry, or therapeutic studies is preferred.* Strong computer, organizational, documentation, and multitasking skills.* Excellent written and verbal communication skills.* Ability to manage multiple priorities and work effectively in a fast-paced laboratory environment.**PHYSICAL DEMANDS AND WORK ENVIRONMENT:*** Must be able to sit and use hands to finger, handle and feel.* Must be able to lift and move packages weighing up to 50 pounds.* Must be able to sit for long periods of time using a computer in a typical office environment in a multi-level facility.* Some activities require repetitive motion and reaching, pulling, or pushing.* In carrying out the duties of the job there will be frequent exposure to fumes and chemical hazards* Duties performed routinely require exposure to blood, body fluid and tissue.*This description reflects management’s assignment of essential functions, it does not proscribe or restrict the tasks that may be assigned. We celebrate diversity and are committed to creating an inclusive environment for all employees.*