Research Scientist II, Antibody Engineering

SRT Therapeutics Inc.; San Diego (CA); On-site; USD 90,000 - 150,000; Full time

Benefits offered by this job

Annual bonus

Stock options

Job summary

A leading biotech company in San Diego seeks a Research Scientist II to join their Protein Sciences team. You will design and optimize therapeutic proteins and antibodies, conduct assays, mentor junior staff, and collaborate with various teams to drive discoveries. A Ph.D. in a relevant field and strong experience in antibody engineering are required. This is a full-time position offering a competitive salary based on skills and experience.

Qualifications

• Ph.D. required with deep technical knowledge in antibody discovery and protein engineering.
• Demonstrated leadership and mentoring experience.
• Evidence of innovation through patents, publications, or conference presentations.

Responsibilities

• Design and optimize proteins and antibodies using rational design techniques.
• Collaborate closely with biology and development teams.
• Mentor junior scientists and research associates.
• Troubleshoot complex technical challenges to meet research objectives.

Skills

Antibody engineering

Protein engineering

Biochemical techniques

Problem-solving

Communication

Education

Ph.D. in Biology, Biochemistry, Molecular Biology, or a related field

Job description

Research Scientist II, Antibody Engineering

Salary range: $90,000.00/yr – $150,000.00/yr (actual pay based on skills and experience). Annual bonus and stock options may be awarded.

Job Title: Research Scientist II, Antibody Engineering
Company: SRT Therapeutics

About the Company

SRT Therapeutics is a San Diego‑based biotech company founded in 2024 by the team behind Prometheus Biosciences, including Steph Targan, MD, Janine Bilsborough, Ph.D., and others who discovered Tulisokibart (MK7240) and its role of TL1A in IBD. Building on the precision medicine approach, SRT will target key pathways that modulate inflammation and promote tissue healing.

Position Summary

SRT seeks a highly motivated, experienced Research Scientist II to join our Protein Sciences team focusing on Antibody Engineering and Kinetics. This central role leads protein engineering efforts to design, optimize and characterize therapeutic proteins and antibodies, driving discovery through development.

Key Responsibilities

• Design and optimize proteins and antibodies using rational design and directed evolution strategies.
• Drive development of therapeutic candidates to address challenging targets and enhance stability, affinity, specificity, and developability.
• Perform comprehensive characterization of antibodies and peptides using biochemical and biophysical techniques (e.g., ELISA, SPR, BLI).
• Conduct binding and functional assays to evaluate candidate performance and therapeutic potential.
• Oversee and manage CRO partnerships for outsourced mammalian expression, purification, and reagent production.

Project Leadership & Scientific Collaboration

• Participate in project planning and contribute to research strategy development.
• Collaborate closely with biology, nonclinical, and CMC development teams to ensure seamless program progression.
• Communicate research findings effectively to internal stakeholders, senior leadership, and external partners.
• Independently design and execute experimental plans to meet research objectives.
• Troubleshoot complex technical challenges and develop innovative solutions.
• Mentor junior scientists and research associates, fostering a culture of scientific excellence.
• Contribute to patent filings, publications, and regulatory documentation.

Qualifications, Education, and Experience

• Ph.D. in Biology, Biochemistry, Molecular Biology, or a related field.
• Deep technical knowledge in antibody discovery and protein engineering.
• Demonstrated leadership and mentoring experience.
• Strong problem‑solving and troubleshooting skills.
• Excellent communication and collaboration abilities.
• Evidence of innovation through patents, publications, or conference presentations.

Preferred Qualifications

• Industry experience advancing therapeutic antibodies from discovery through development.
• Familiarity with developability assessments and biophysical characterization.
• Track record of advancing candidates to clinical development.

Seniority level

Associate

Employment type

Full‑time

Job function

Science

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