Associate Director - Protein Sciences

EPM Scientific; Menlo Park (CA); On-site; USD 200,000 - 250,000; Full time

Job summary

EPM Scientific is seeking a senior scientific leader to drive antibody characterization, develop-ability assessments, and early CMC activities for a stealth-mode biotech. You will perform hands-on studies, manage CROs/CDMOs, and guide IND-enabling development to build a robust development program.

The role partners with the CSO, leads cross-functional teams, and may expand a team as the company grows; candidates should have extensive antibody/protein therapeutics experience and a track record in

Qualifications

• PhD preferred; MS/BS with relevant experience acceptable.
• 5+ years in senior roles; 8+ for associate director; 10+ for director in industry.
• Strong experience with therapeutic antibodies and protein biologics.
• Experience supporting IND-enabling development and early CMC activities.

Responsibilities

• Lead characterization and developability assessments of monoclonal and bispecific antibodies.
• Oversee protein expression/purification using mammalian systems.
• Coordinate analytical/biophysical studies (SEC-HPLC, CE-SDS, DLS, etc.).
• Assess aggregation, stability, charge variants, fragmentation, solubility, and CQAs.
• Design and execute formulation and forced degradation studies.
• Troubleshoot developability challenges including low expression and manufacturing liabilities.
• Integrate analytical data to support candidate selection.
• Manage CROs, CDMOs, and analytical partners with timelines and budgets.
• Support process development, tech transfer, and manufacturing readiness.
• Contribute to pre-IND and IND CMC strategy.
• Collaborate with teams in the U.S. and China.

Skills

Antibody characterization

Developability assessment

Protein sciences

IND/CMC experience

CRO/CDMO management

Education

PhD preferred in Protein Chemistry/Biochemistry/Biophysics/Pharmaceutical Sciences/Molecular Biology or related field

MS/BS with relevant experience

Job description

Salary: USD200000 - USD250000 per year

Company Overview

Our client is a stealth-mode biotechnology company developing next-generation antibody and protein therapeutics. With research teams in both the U.S. and China, the company is advancing multiple programs toward IND-enabling studies and is seeking a key scientific hire to help build its development organization from the ground up.

Position Summary

This individual will serve as a technical leader supporting antibody characterization, develop-abilityassessment, protein sciences, and early CMC activities. The role combines hands-on scientific work, CRO/CDMO management, and IND-enabling development efforts.

The position will work closely with the CSO and have the opportunity to help build and lead a team as the company grows.

Key Responsibilities

• Lead characterization and develop-abilityassessments of monoclonal antibodies, bispecific antibodies, multispecific antibodies, and other protein therapeutics.
• Perform protein expression and purification using mammalian expression systems (HEK293, Expi293, or similar).
• Execute and interpret analytical and biophysical studies including SEC-HPLC, CE-SDS, DLS, HIC, IEX, icIEF, DSF, nanoDSF, and DSC.
• Assess aggregation, stability, charge variants, fragmentation, solubility, and other critical quality attributes.
• Design and execute formulation and forced degradation studies.
• Troubleshoot develop abilitychallenges including low expression, aggregation, poor stability, and manufacturing liabilities.
• Integrate analytical, biophysical, and functional data to support candidate selection.
• Manage CROs, CDMOs, and analytical partners, including timelines, budgets, and deliverables.
• Support process development, tech transfer, analytical development, and manufacturing readiness activities.
• Contribute to pre-IND and IND CMC strategy, including Module 3 documentation.
• Collaborate closely with scientific teams in both the U.S. and China.
• Participate in frequent cross-functional meetings and occasional travel.

Qualifications

• PhD preferred (MS/BS considered with relevant experience) in Protein Chemistry, Biochemistry, Biophysics, Pharmaceutical Sciences, Molecular Biology, or related field.
• 5+ years (Senior Scientist), 8+ years (Associate Director), or 10+ years (Director) of industry experience.
• Strong experience with therapeutic antibodies and protein biologics.
• Experience with antibody characterization and develop abilityassessments.
• Familiarity with bispecific, multispecific, or engineered antibody formats preferred.
• Experience supporting IND-enabling development and early CMC activities.
• Track record managing CROs and/or CDMOs.
• Comfortable working in a fast-paced startup environment.
• Authorization to work in the U.S. without sponsorship.

Preferred Qualifications

• IND submission or Module 3 experience.
• Autoimmune or immunology therapeutic experience.
• Experience working with teams in China.
• Startup or early-stage biotech experience.

What They're Looking For

Must-Have

• Antibody/protein therapeutics experience
• Protein characterization & develop-abilityexpertise
• Early CMC or IND-support experience
• CRO/CDMO management

Nice-to-Have

• Bispecific/multispecific antibody experience