Scientist II: Complex In Vitro Models & Organoids

Biopharma Careers; Maryland; On-site; USD 90,000 - 150,000; Full time

Job summary

AbbVie Immunology is seeking a scientist to support the design, execution, and interpretation of in vitro studies on drug candidate molecules and target validation. This role focuses on primary human cells, organoids and complex 3D systems to characterize potency and mechanism of action.

The successful candidate will analyze quantitative data, present findings, and maintain meticulous research records in a fast-paced, collaborative environment within AbbVie Immunology.

Qualifications

• BS or MS in Biological science with focus in Immunology, Biochemistry, Molecular Biology, Cell Biology, or a related discipline with typically 7+ (BS) or 5+ (MS) years of relevant lab experience.
• Proficiency in culturing primary human immune cells, immortalized cell lines, and organ/tissue cultures, including differentiated cells and iPSCs, using standard tissue culture and transwell systems.
• Experience developing and applying complex in vitro models, including co-culture and advanced 3D cellular systems, to support discovery programs.
• Experience designing experiments to study cell signaling, phosphoproteins, second messenger pathways, cell proliferation, gene reporter assays, and soluble mediator release.
• Expertise in ELISA/MSD, alphaLISA, HTRF, PCR, multicolor flow cytometry, high content microscopy, and related methodologies.
• Demonstrated motivation, strong attention to detail, scientific curiosity, and eagerness to learn novel in vitro pharmacology techniques.
• Strong background in statistics with proficiency in spreadsheets and curve-fitting software such as Microsoft Excel and GraphPad Prism.
• Skilled in leveraging automation to increase assay robustness, improve throughput, and enable miniaturization of experimental workflows.

Responsibilities

• Design and perform biochemical and cellular studies of drug potency and mechanism of action using primary human blood cells, cell lines and complex in vitro systems such as organoids or organ-on-chip models.
• Analyze, interpret and clearly communicate quantitative data.
• Conduct and organize activities and communicate through oral and written presentations.
• Read and apply relevant scientific literature.
• Maintenance of accurate and current records of research.

Skills

Immunology

In vitro model development

Cell signaling

Data analysis

Automation

Collaboration

Organoid/organ-on-chip experience

Statistics (Excel, GraphPad Prism)

Education

BS/MS in Biological sciences

Tools

ELISA/MSD/HTRF

PCR

Flow cytometry

High-content imaging

Job description

AbbVie Immunology is seeking a scientist to support the design, execution, and interpretation of in vitro studies on drug candidate molecules and target validation. This role focuses on primary human cells, organoids and complex 3D systems to characterize potency and mechanism of action.

The successful candidate will analyze quantitative data, present findings, and maintain meticulous research records in a fast-paced, collaborative environment within AbbVie Immunology.