Scientist I, Dermatology/Immunology

AbbVie Inc.; Cambridge (MA); Vor Ort; USD 90.000 - 120.000; Vollzeit

Zusammenfassung

AbbVie Inc. in Cambridge, MA is seeking a Scientist I to join the Dermatology Discovery team within Immunology R&D.

The role focuses on identifying and validating therapeutics for inflammatory skin diseases using human disease transcriptomics, multi-omics, and wet-bench studies to drive translational insights. The candidate will perform in vitro models with keratinocytes, fibroblasts, and immune cells, applying assays and analyses to advance preclinical research.

Qualifikationen

• Bachelor’s degree in molecular biology, immunology or related biological sciences (BS/BA) with 5 years of experience.
• Master’s degree with 2 years of experience is desirable.

Aufgaben

• Culture sterile cell lines and primary cells.
• Process and analyze ex-vivo human tissues for disease endpoints.
• Perform analyses: Flow cytometry, qPCR, ELISA and multiplex assays.
• Conduct Western blotting and microscopy.
• Develop assays monitoring cellular processes and analyze data.
• Maintain detailed records in electronic lab notebook.

Kenntnisse

Sterile cell culture

Flow cytometry

Quantitative PCR

Protein analysis

Western blotting

Microscopy

Data analysis

In vitro models

Ausbildung

Bachelor’s degree in molecular biology/immunology

Master’s degree with 2 years experience

Jobbeschreibung

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on LinkedIn, Facebook , Instagram , X and YouTube.

Position Overview

AbbVie's Immunology R&D organization is looking for a highly motivated Scientist I to join our Dermatology Discovery team at the Cambridge Research Center in Cambridge, MA. This researcher will contribute to the identification and validation of novel therapeutics for inflammatory skin diseases. The Dermatology Discovery team applies human disease transcriptomic and multi-omics data sets in combination with wet-bench science to perform mechanistic in vitro studies with the overarching goal to elucidate disease-driving mechanisms that will advance innovative therapeutic strategies. The successful candidate will play a key role in the preclinical research team by conducting in vitro models focusing on human translation to HS and PsO.

Candidate Profile

The ideal candidate is scientifically curious, collaborative, enthusiastic, skilled, and dedicated. This position requires passion, attention to detail, prior hands-on experience, and teamwork within a fast-paced drug discovery environment.

Key Responsibilities

• Sterile cell culture (cell lines and primary human and murine cells)
• Process and analyze ex-vivo human tissues for disease-relevant endpoints
• Perform analyses using the following techniques:
• Flow cytometry
• Quantitative PCR
• Protein analyses – ELISA, MSD and multiplex assays
• Western blotting
• Microscopy
• Develop and implement assays that monitor cellular processes
• Analyze data using appropriate statistical methods and communicate findings through presentations and scientific discussions
• Maintain detailed experimental records and ensure compliance with electronic laboratory notebook
• Prior hands-on experience with keratinocytes, fibroblasts, and immune cells (Th17 T cell differentiation, macrophage polarization) is a plus
• Candidates with prior experience in complex human in vitro model will receive extra consideration

Key Requirements

• Bachelor’s degree in molecular biology, immunology or other biological sciences (BS/BA) with 5 years of experience
• Master’s degree with 2 years of experience is desired

Key AbbVie Competencies

• Builds strong relationships with peers and cross functionally with partners outside of the team to enable high performance
• Learns fast, grasps the "essence" and can change course quickly
• Raises the bar and is never satisfied with the status quo
• Creates a learning environment, open to suggestions and experimentation for improvement
• Embraces the ideas of others and nurtures innovation to make possibilities real

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.

We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.

This job is eligible to participate in our short-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company’s sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html