Scientist, HSPC Vector Engineering

Syenex, Inc

Evanston (IL)

On-site

USD 120,000 - 190,000

Full time

14 days+

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Job summary

Syenex, Inc. is seeking an accomplished Scientist with expertise in hematopoietic stem cell biology to join the Discovery Team.

You will develop and evaluate next-generation delivery vectors for engineering human hematopoietic stem and progenitor cells (HSPCs), combining primary HSPC biology, vector design, and quantitative assays. The ideal candidate has hands-on experience with primary CD34+ cells, strong flow cytometry skills, and a background in genome engineering or gene delivery.

Qualifications

PhD in cell biology, molecular biology, bioengineering, biomedical engineering, immunology, hematology, or related field.
Substantial hands-on experience culturing and manipulating primary human CD34+ cells.
Strong understanding of HSPC biology and differentiation states.
Experience with multi-color flow cytometry for phenotype and quantification.
Experience with gene delivery or genome engineering of mammalian cells.
Strong mammalian cell culture skills and aseptic technique.
Experience designing experiments, troubleshooting, and interpreting data.
Commitment to rigor, data quality, and reproducibility.
Excellent written and verbal scientific communication.

Responsibilities

Design, build, and evaluate gene delivery vectors for human HSPCs.
Evaluate vector performance: delivery efficiency, specificity, viability, phenotype.
Cultivate and characterize primary CD34+ cells; develop quantitative assays and flow panels.
Design and contribute to in vivo studies of vector performance and HSPC targeting.
Develop scalable, high-throughput screening workflows for many vector designs.
Independently design, execute, troubleshoot, and interpret experiments.
Develop and document SOPs to improve reproducibility and transfer workflows.
Maintain thorough experimental records and sample metadata.
Provide mentorship to junior scientists and research associates.
Present results to project teams and leadership.