Scientist – Functional Genomics

Fladger Associates; Ridgefield (CT); On-site; USD 110,000 - 160,000; Full time

Job summary

Fladger Associates in Ridgefield, CT, is seeking a Scientist III in Cell Biology & Functional Genomics to support discovery programs with automation platforms, mammalian cell culture, and functional genomics. You will execute automated cell culture and assay workflows and contribute to iPSC-derived organoid and NGS-related work, with training provided as needed.

The role emphasizes meticulous data handling, sample tracking, and adherence to SOPs, with collaboration across cell biology,

Qualifications

• Master's degree with 3+ years of relevant experience in cell biology, genomics, or related discipline.
• Strong hands-on experience with mammalian cell culture and cell-based assays.
• Hands-on NGS workflow experience (bulk RNA-seq, scRNA-seq, snRNA-seq) and library prep.
• Some exposure to automated workflows; automation programming not required.

Responsibilities

• Design, execute, and analyze cell-based experiments supporting target validation and discovery research.
• Operate and monitor automated cell-based and molecular assay workflows; troubleshoot as needed.
• Perform tissue, cell, and nuclei dissociation and execute NGS workflows.
• Maintain accurate records and ensure data integrity per SOPs.
• Collaborate across cell biology, automation, genomics, and bioinformatics teams.

Skills

Attention to detail

Troubleshooting

Collaboration

Data integrity

Education

Master's degree + 3+ years

Bachelor's degree + 7+ years

Tools

Laboratory automation platforms

NGS workflows

iPSC culture systems

Job description

• Excellent employment opportunity for a Scientist III Cell Biology & Functional Genomics in the Ridgefield, CT area.
• The successful candidate will support discovery research programs within Cardiovascular-Renal-Metabolic Diseases through hands-on operation of laboratory automation platforms, mammalian cell culture, cell-based assays, and functional genomics studies.
• The candidate will execute and monitor established automated cell culture and assay workflows and support automated iPSC-derived kidney organoid processes and next-generation sequencing (NGS)-related work, with platform- and workflow-specific training provided as needed.
• The role requires reliable execution of automation and NGS workflows. Success requires exceptional attention to detail, careful sample and reagent tracking, precise adherence to established protocols, and independent troubleshooting of routine experimental or platform issues.
• Design, execute, and analyze cell-based experiments supporting target validation and discovery research, including routine mammalian cell culture, assay execution, image-based analysis, and iPSC-derived cell workflows.
• Operate and monitor established laboratory automation workflows for cell-based and molecular assays, troubleshoot routine issues, and **escalate** complex problems appropriately.
• Perform tissue, cell, and nuclei dissociation and execute NGS workflows for bulk RNA-seq, single-cell RNA-seq, single-nucleus RNA-seq, and related applications, including library preparation, quality control, quantification, normalization, sequencing setup, and sequencer operation.
• Perform routine molecular biology techniques, including DNA/RNA extraction, PCR and qPCR, nucleic acid and protein quantification, Western blotting, and basic sample preparation; analyze and interpret results, identify technical issues, and communicate findings and recommended follow-up clearly.
• Maintain accurate sample, reagent, consumable, experimental metadata, and electronic laboratory notebook records while complying with SOPs, safety requirements, company policies, and data integrity standards.
• Collaborate across cell biology, automation, genomics, and bioinformatics groups.

Experience:

• Master's degree with 3+ years of relevant experience; or Bachelor's degree with 7+ years of relevant experience; or Equivalent combination of education and experience in cell biology, molecular biology, genomics, or a related scientific discipline.Strong hands-on experience with mammalian cell culture, cell biology, and cell-based assay execution.
• Hands-on NGS workflow experience, including tissue, cell, and/or nuclei dissociation, sequencing library preparation, quality control, and quantification for bulk RNA-seq, single-cell RNA-seq, single-nucleus RNA-seq, or related applications.
• Some hands-on experience with laboratory automation, automated instrumentation, or standardized high-throughput workflows, with the ability and interest to develop further expertise in operating and troubleshooting automated cell-based and molecular assays; automation programming is not required.
• Exceptional attention to detail and demonstrated ability to accurately execute lengthy, multi-step protocols while maintaining sample integrity, data quality, and complete documentation.
• Ability to independently troubleshoot routine experimental or operational issues, communicate clearly, and work effectively in a collaborative research environment.

Desired Skills:

• Experience running laboratory automation platforms for cell-based or molecular assays.
• Experience with sequencing run setup and sequencer operation. Instrument-specific operation can be trained when required.
• Experience with human induced pluripotent stem cell culture, differentiation, characterization, or iPSC-derived cell assays.
• Experience with kidney organoid culture systems.