Scientist III Cell Biology & Functional Genomics

Boehringer Ingelheim; Ridgefield (CT); On-site; USD 90,000 - 130,000; Full time

Job summary

Boehringer Ingelheim in Ridgefield, CT, is seeking a candidate to support discovery research in Cardiovascular-Renal-Metabolic Diseases with hands-on lab automation, mammalian cell culture, and iPSC-derived organoid workflows. The role involves executing automated cell culture and NGS-related tasks, with training provided as needed.

Ideal candidates will have hands-on experience in cell biology, sequencing workflows, and maintaining meticulous records while collaborating across biology,

Qualifications

• Hands-on mammalian cell culture and basic assays; image-based analysis may be included.
• Experience in RNA/DNA work and library prep.
• Experience with automated workflows and organoid cultures.
• Strong documentation and data integrity.
• Ability to troubleshoot routine lab issues.

Responsibilities

• Design, execute, and analyze cell-based experiments for validation and discovery.
• Operate and monitor lab automation workflows and troubleshoot issues.
• Perform dissociation and execute NGS workflows including library prep and QC.
• Carry out routine molecular biology techniques and data interpretation.
• Maintain meticulous records and collaborate across teams.
• Collaborate with genomics and bioinformatics groups.

Skills

Mammalian cell culture

NGS workflows

Laboratory automation

iPSC-derived organoids

Cell biology techniques

Education

Master's degree + 3+ years in relevant field

Bachelor's degree + 7+ years in relevant field

Equivalent combination of education and experience

Tools

NGS instruments (sequencers)

Job description

The successful candidate will support discovery research programs within Cardiovascular-Renal-Metabolic Diseases through hands-on operation of laboratory automation platforms, mammalian cell culture, cell-based assays, and functional genomics studies. The candidate will execute and monitor established automated cell culture and assay workflows and support automated iPSC-derived kidney organoid processes and next-generation sequencing (NGS)-related work, with platform- and workflow-specific training provided as needed.

The role requires reliable execution of automation and NGS workflows. Success requires exceptional attention to detail, careful sample and reagent tracking, precise adherence to established protocols, and independent troubleshooting of routine experimental or platform issues.

Duties & Responsibilities

• Design, execute, and analyze cell-based experiments supporting target validation and discovery research, including routine mammalian cell culture, assay execution, image-based analysis, and iPSC-derived cell workflows.
• Operate and monitor established laboratory automation workflows for cell-based and molecular assays, troubleshoot routine issues, and elevate complex problems appropriately.
• Perform tissue, cell, and nuclei dissociation and execute NGS workflows for bulk RNA-seq, single-cell RNA-seq, single-nucleus RNA-seq, and related applications, including library preparation, quality control, quantification, normalization, sequencing setup, and sequencer operation.
• Perform routine molecular biology techniques, including DNA/RNA extraction, PCR and qPCR, nucleic acid and protein quantification, Western blotting, and basic sample preparation; analyze and interpret results, identify technical issues, and communicate findings and recommended follow-up clearly.
• Maintain accurate sample, reagent, consumable, experimental metadata, and electronic laboratory notebook records while complying with SOPs, safety requirements, company policies, and data integrity standards.
• Collaborate across cell biology, automation, genomics, and bioinformatics groups.
• Strong hands-on experience with mammalian cell culture, cell biology, and cell-based assay execution.
• Hands-on NGS workflow experience, including tissue, cell, and/ or nuclei dissociation, sequencing library preparation, quality control, and quantification for bulk RNA-seq, single-cell RNA-seq, single-nucleus RNA-seq, or related applications.
• Some hands-on experience with laboratory automation, automated instrumentation, or standardized high-throughput workflows, with the ability and interest to develop further expertise in operating and troubleshooting automated cell-based and molecular assays; automation programming is not required.
• Exceptional attention to detail and demonstrated ability to accurately execute lengthy, multi-step protocols while maintaining sample integrity, data quality, and complete documentation.
• Ability to independently troubleshoot routine experimental or operational issues, communicate clearly, and work effectively in a collaborative research environment.

Desired Skills

• Experience running laboratory automation platforms for cell-based or molecular assays.
• Experience with sequencing run setup and sequencer operation. Instrument-specific operation can be trained when required.
• Experience with human induced pluripotent stem cell culture, differentiation, characterization, or iPSC-derived cell assays.
• Experience with kidney organoid culture systems.
• Master's degree with 3+ years of relevant experience; or
• Bachelor's degree with 7+ years of relevant experience; or
• Equivalent combination of education and experience in cell biology, molecular biology, genomics, or a related scientific discipline.