Scientist III Cell Biology & Functional Genomics

TechMind RPO; Ridgefield (CT); On-site; USD 110,000 - 140,000; Full time

Job summary

TechMind RPO is seeking a Scientist III in Ridgefield, CT to support discovery programs in Cardiovascular-Renal-Metabolic diseases. You will operate automated cell culture and assays, perform NGS library prep, and contribute to organoid workflows with strict sample tracking.

The candidate will design and analyze cell-based experiments, troubleshoot platform issues, and collaborate with cross-functional teams to advance target validation and discovery research.

Qualifications

• Master's degree with 3+ years of relevant experience; or Bachelor's with 7+ years of relevant experience in cell biology, molecular biology, genomics, or related discipline.
• Experience with mammalian cell culture, cell-based assays, and NGS workflows.
• Some experience with lab automation or high-throughput workflows; automation programming not required.
• Exceptional attention to detail and ability to follow lengthy multi-step protocols while maintaining data integrity.
• Ability to troubleshoot routine experimental or operational issues and communicate findings clearly.

Responsibilities

• Operate automated cell culture and assay workflows.
• Support automated iPSC-derived kidney organoid processes and NGS-related work.
• Execute and monitor cell culture and assay workflows with precise sample tracking.
• Perform tissue, cell, and nuclei dissociation and RNA sequencing workflows (bulk and single-cell).
• Conduct basic molecular biology techniques (DNA/RNA extraction, PCR, Western blot).
• Maintain accurate lab records and comply with SOPs and safety policies.
• Collaborate across cell biology, automation, genomics, and bioinformatics groups.

Skills

Mammalian cell culture

NGS workflows

Automated lab platforms

Data integrity & documentation

Troubleshooting

Collaborative research

Education

Master's degree

Bachelor's degree

Tools

Laboratory automation platforms

NGS instrumentation operation

Job description

Responsibilities

• Excellent employment opportunity for a Scientist III Cell Biology & Functional Genomics in the Ridgefield, CT area.
• The successful candidate will support discovery research programs within Cardiovascular-Renal-Metabolic Diseases through hands-on operation of laboratory automation platforms, mammalian cell culture, cell-based assays, and functional genomics studies.
• The candidate will execute and monitor established automated cell culture and assay workflows and support automated iPSC-derived kidney organoid processes and next-generation sequencing (NGS)-related work, with platform- and workflow-specific training provided as needed.
• The role requires reliable execution of automation and NGS workflows. Success requires exceptional attention to detail, careful sample and reagent tracking, precise adherence to established protocols, and independent troubleshooting of routine experimental or platform issues.
• Design, execute, and analyze cell-based experiments supporting target validation and discovery research, including routine mammalian cell culture, assay execution, image-based analysis, and iPSC-derived cell workflows.
• Operate and monitor established laboratory automation workflows for cell-based and molecular assays, troubleshoot routine issues, and elevate complex problems appropriately.
• Perform tissue, cell, and nuclei dissociation and execute NGS workflows for bulk RNA-seq, single-cell RNA-seq, single-nucleus RNA-seq, and related applications, including library preparation, quality control, quantification, normalization, sequencing setup, and sequencer operation.
• Perform routine molecular biology techniques, including DNA/RNA extraction, PCR and qPCR, nucleic acid and protein quantification, Western blotting, and basic sample preparation; analyze and interpret results, identify technical issues, and communicate findings and recommended follow-up clearly.
• Maintain accurate sample, reagent, consumable, experimental metadata, and electronic laboratory notebook records while complying with SOPs, safety requirements, company policies, and data integrity standards.

• Collaborate across cell biology, automation, genomics, and bioinformatics groups.

  Experience:

• Master's degree with 3+ years of relevant experience; or Bachelor's degree with 7+ years of relevant experience; or Equivalent combination of education and experience in cell biology, molecular biology, genomics, or a related scientific discipline.
• Strong hands-on experience with mammalian cell culture, cell biology, and cell-based assay execution.
  Hands-on NGS workflow experience, including tissue, cell, and/or nuclei dissociation, sequencing library preparation, quality control, and quantification for bulk RNA-seq, single-cell RNA-seq, single-nucleus RNA-seq, or related applications.
• Some hands-on experience with laboratory automation, automated instrumentation, or standardized high-throughput workflows, with the ability and interest to develop further expertise in operating and troubleshooting automated cell-based and molecular assays; automation programming is not required.
• Exceptional attention to detail and demonstrated ability to accurately execute lengthy, multi-step protocols while maintaining sample integrity, data quality, and complete documentation.
• Ability to independently troubleshoot routine experimental or operational issues, communicate clearly, and work effectively in a collaborative research environment.
  

Desired Skills

• Experience running laboratory automation platforms for cell-based or molecular assays.
• Experience with sequencing run setup and sequencer operation. Instrument-specific operation can be trained when required.
• Experience with human induced pluripotent stem cell culture, differentiation, characterization, or iPSC-derived cell assays.
• Experience with kidney organoid culture systems.