Scientist – Erythroid Biology

Biopharma Careers; Thousand Oaks (CA); On-site; USD 115,000 - 156,000; Full time

Benefits offered by this job

Retirement plan

Medical insurance

Dental insurance

Vision coverage

Life insurance

Disability insurance

Flexible spending accounts

Bonus program

Stock incentives

Paid time off

Flexible work

Job summary

Amgen is seeking a Scientist – Erythroid Biology to design and execute experiments, analyze results, and present study findings. You will help develop human primary cell systems and validate targets related to RNA therapeutics, contributing to IND-enabling programs within cross-functional teams.

The role emphasizes collaboration across Delivery/chemistry, Translational and biomarker groups, with a focus on erythroid biology and hematopoiesis. Competitive benefits and career growth are offered.

Qualifications

• PhD or equivalent in a relevant biology field.
• Advanced knowledge in erythroid biology and hematopoiesis preferred.
• Experience with siRNA/RNA therapeutics is a plus.

Responsibilities

• Design and conduct in vitro and ex vivo assays to evaluate siRNA delivery and function.
• Develop human primary cell-based systems.
• Support target validation and mechanism-of-action studies for siRNA therapeutics.
• Collaborate with Delivery/chemistry, Translational and biomarker teams.
• Establish and optimize Flow cytometry panels, qPCR/RNA readouts.
• Contribute to IND-enabling studies and data packages.

Skills

Erythroid biology

Flow cytometry

RNA analysis

Data interpretation

Cross-functional collaboration

Education

Doctorate degree

Master’s degree + 2 years experience

Bachelor’s degree + 4 years experience

Tools

qPCR

RNA assays

Cell culture

Job description

Career Category

Research

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission, to serve patients living with serious illnesses, drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases.

With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity-related conditions.

As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Scientist – Erythroid Biology

What you will do

Let’s do this. Let’s change the world. In this vital role you will. A Scientist at Amgen is responsible for designing and conducting experiments, analyzing results, and interpreting data. They prepare technical reports, summaries, and protocols and present study results at team meetings. They also assist in maintaining lab equipment, troubleshooting issues, and ensuring safety protocols are adhered to.

Responsibilities

• Design and execute in vitro and ex vivo assays to evaluate siRNA delivery and function
• Develop human primary cell-based systems
• Support target validation and mechanism-of-action studies for siRNA therapeutics
• Collaborate with Delivery/chemistry teams, Translational and biomarker teams
• Establish and optimize Flow cytometry panels, qPCR / RNA-based readouts
• Contribute to IND-enabling studies and data packages

Basic Qualifications

• Doctorate degree
• Master’s degree and 2 years scientific experience
• OR
• Bachelor's degree and 4 years scientific experience

Preferred Qualifications

• Experience with siRNA / RNA therapeutics (delivery or functional assays), Erythroid biology and hematopoiesis.
• Strong background in Flow cytometry (multi-color), Cell-based functional assays
• Familiarity with gene expression (qPCR, RNA assays), target engagement assays Experience working in cross-functional drug discovery teams
• Knowledge on Hemoglobinopathies, conjugated delivery systems, CRISPR or gene editing is a plus

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Application Deadline

External/Internal postings:

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Internal only posting (or Pre-ID candidate):

Amgen anticipates accepting applications however, we may continue accepting applications beyond this date if we do not receive a sufficient number of candidates.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Salary Range

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

115,393.45USD -156,120.55USD