Principal Research Scientist I, Multispecifics Engineering

SmartRecruiters, Inc.; Worcester (MA); On-site; USD 125,000 - 237,000; Full time

Job summary

AbbVie, in the United States, is seeking a Principal Research Scientist I to lead multispecific engineering efforts for multiple therapeutic areas. The role focuses on engineering, production, and characterization of multispecific biologics across projects, with emphasis on design trends and platform advancement.

The ideal candidate will drive cross-functional collaboration, manage timelines, mentor scientists, and contribute to publications and patents while advancing AbbVie's discovery

Qualifications

• PhD or MS in Biochemistry, Biochemical Engineering, or related field.
• 6+ years (PhD) or 12+ years (MS) in multispecific or antibody engineering.
• Experience designing, expressing, and purifying proteins, biologics, multispecifics.
• Knowledge of multispecific landscape and therapeutic areas.
• Excellent organizational and communication skills; team player.

Responsibilities

• Design, engineer, and produce multispecific biologics for multiple therapies.
• Serve as SME on cross-functional teams, providing updates and recommendations.
• Lead on 1–2 projects, manage molecule-related activities and timelines.
• Identify and solve technical problems; implement new research ideas.
• Ensure consistency and quality of technical reports.
• Present work internally and at conferences; publish papers or patents.

Skills

Biologics engineering

Multispecific engineering

Project management

Cross-functional collaboration

Scientific communication

Team leadership

Molecule design

Analytical thinking

Education

PhD in Biochemistry or related

MS in Biochemistry or related

Tools

Mass spectrometry

Protein purification

Job description

Principal Research Scientist I, Multispecifics Engineering

• Full-time
• Salary Min: 124500
• Salary Max: 236500
• Workday Global Grade: 19
• Compensation: USD 124,500 - USD 236,500 - yearly

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on LinkedIn, Facebook , Instagram , X and YouTube.

The Multispecifics Engineering group at AbbVie is seeking a highly skilled, self-motivated scientist to join a dynamic team supporting Discovery Biotherapeutics. In this role, the successful candidate will drive the engineering, production, and characterization of multispecific biopharmaceutical products across multiple projects. The ideal candidate has extensive experience in biologics and multispecifics design, with a proven track record of applying multispecific engineering to advance discovery-stage programs, as well as experience in people and project management. We are looking for an enthusiastic, creative scientist ready to make tangible contributions to the pipeline.

Key responsibilities:

Design, engineer, and produce multispecific biologics supporting multiple therapeutic areas.

Serve as the Multispecifics Engineering representative and subject matter expert on cross-functional teams—including Therapeutic Areas, Discovery Biotherapeutics, and Development Sciences—providing project updates, analysis, and recommendations.

Serve as Biologics Lead on 1–2 projects, managing molecule-related activities, building timelines with the TA Lead, contributing to key decision-making, and ensuring timely transitions from hit generation through candidate nomination.

Identify and solve technical problems independently; conceive and implement innovative research ideas that advance the group's and AbbVie's mission.

Ensure the consistency and quality of technical reports.

Present original work internally across departments and at internal and external scientific conferences; may author or co-author peer-reviewed papers or patents.

Minimum Qualifications:

PhD or MS degree in Biochemistry, Biochemical Engineering, or a related discipline.

6+ (PhD) or 12+ (MS) years of experience in multispecific or antibody engineering

Experience with the design, expression, and purification of proteins, biologics, fragments, or multispecifics (e.g., bispecifics, trispecifics, bispecific protein fusions).

In-depth knowledge of the multispecific landscape, including design trends and technologies, and the application of the multispecific modality across therapeutic areas such as immunology, oncology, and neuroscience.

Ability to recognize emerging areas of interest in multispecific and antibody engineering and related fields, connecting research ideas to build next-generation molecules and advance platforms and programs.

Excellent organizational skills, with the ability to manage multiple projects simultaneously.

Strong team player able to operate effectively in a fast-paced, multidisciplinary environment.

Goal-oriented team player with excellent verbal and written communication skills and a strong can-do attitude.

PreferredQualifications:

Experience coordinating with CROs for protein production.

Expert understanding of protein expression,separation, andanalytical technologiesincluding mass spectrometry analysis of multispecifics.

Experience with technologies beyond recombinantproteinproduction for generating multispecifics, enabling high-throughput screening to support agonist programs or screen combinatorial multispecific space(e.g. mammalian display).

Knowledge of biologic pipeline progression from exploratory through candidate nomination; program management experience preferred.

Builds strong relationships with peers and cross functionally with partners outside of the team to enable high performance.

Learns fast, grasps the “essence” and can change the course quickly where indicated.

Raises the bar and is never satisfied with the status quo.

Creates a learning environment, open to suggestions and experimentation for improvement.

Embraces the ideas of others, nurtures innovation and manages innovation to reality.

• Continuous sitting for prolonged periods (more than 2 consecutive hours in an 8 hour day)

Experience managing direct reports, including performance evaluations and development planning.

Recognized in the scientific community through a sustained record of peer-reviewed publications and patents.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeof this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location, andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture.

We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.

This job is eligible toparticipatein our long-term incentiveprograms.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of any bonus,commission, incentive, benefits, or any other form ofcompensation andbenefitsthat are allocable to a particular employeeremains in the Company's sole andabsolutediscretion unless and until paid andmay bemodifiedat the Company’s sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

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