Scientist (Bioconjugation)

Infotree Global Solutions; Thousand Oaks (CA); On-site; USD 120,000 - 170,000; Full time

Job summary

Infotree Global Solutions in Thousand Oaks, CA seeks a hands-on Scientist – Bioconjugation to advance next-generation antibody-drug conjugates in the Emerging Proximity Biology group.

PhD preferred; master's with relevant experience or bachelor's with years in ADC generation, purification, and analytical characterization will also be considered. You will design, generate, and characterize ADCs, using HIC, SEC, HPLC, and MS, and collaborate across chemistry and biology teams.

Qualifications

• PhD in chemistry, chemical biology, biochemistry or related field
• Alternatively MSc with 1–2 years relevant laboratory experience
• Alternatively BSc with 2–3 years relevant laboratory experience

Responsibilities

• Design, generate, purify, and characterize antibody–drug conjugates with diverse linker–payload chemistries and novel payloads
• Use site-specific and conventional conjugation strategies to support discovery programs
• Perform analytical characterization of ADCs, including DAR, conjugate purity, aggregation, and heterogeneity
• Contribute to design and evaluation of novel linker–payload constructs and select conjugation chemistries
• Collaborate with chemistry, protein engineering, and biology teams to advance ADC modalities
• Analyze and interpret experimental data, troubleshoot challenges, and document results clearly

Skills

ADC generation

ADC characterization

DAR attributes

Education

Doctorate in chemistry/chemical biology/biochemistry

Master's + 1–2 years relevant experience

Bachelor's + 2–3 years relevant experience

Job description

Scientist – Bioconjugation: Emerging Proximity Biology, Induced Proximity Platform

IDEAL CANDIDATE: Hands-on bioconjugation scientist with direct therapeutic antibody-drug conjugate or related antibody conjugate generation experience. PhD preferred; master’s plus several years of directly relevant industry experience acceptable. Must independently generate, characterize, interpret analytical results, and deliver molecules with minimal ramp-up.

The Emerging Proximity Biology group within the Induced Proximity Platform at Client is seeking a highly motivated scientist to join our state-of-the-art research facility at the Client headquarters campus in Thousand Oaks, CA. The qualified candidate will work at the interface of bioconjugation chemistry, synthetic chemistry, and chemical biology to support the discovery and development of next-generation antibody‑drug conjugates (ADCs) incorporating novel therapeutic payloads and linker technologies.

Top 3 Must Have Skill Sets:

• Hands‑on experience with antibody‑drug conjugate (ADC) generation, including antibody conjugation, purification, and analytical characterization.
• Experience with analytical techniques relevant to ADC characterization, including hydrophobic interaction chromatography (HIC), size‑exclusion chromatography (SEC), HPLC, and mass spectrometry.
• Familiarity with ADC quality attributes, including drug‑to‑antibody ratio (DAR), conjugate purity, aggregation, and heterogeneity.

Responsibilities include (but are not limited to):

• Design, generate, purify, and characterize antibody‑drug conjugates incorporating diverse linker‑payload chemistries and novel payloads.
• Utilize varying antibody conjugation strategies, including site‑specific and conventional conjugation approaches, to support discovery programs.
• Perform analytical characterization of antibody conjugates, including determination of drug‑to‑antibody ratio (DAR), assessment of conjugate purity and aggregation, and evaluation of compound heterogeneity.
• Contribute to the design and evaluation of novel linker‑payload constructs, including selection of conjugation chemistries, assessment of synthetic feasibility, and collaboration with chemistry teams to support linker‑payload development.
• Collaborate with multidisciplinary teams across chemistry, protein engineering, and biology to advance novel antibody‑based therapeutic modalities.
• Analyze and interpret experimental data, troubleshoot technical challenges, and communicate results through clear documentation, reports, and project updates.

Basic Qualifications

• Doctorate degree in chemistry, chemical biology, biochemistry, or a related scientific discipline OR
• Master's degree and 1–2 years of relevant laboratory experience OR
• Bachelor's degree and 2–3 years of relevant laboratory experience.