Scientist, Biochemistry I or II

1000 Pacific Biosciences of California, Inc.; Menlo Park (CA); On-site; USD 97,000 - 168,000; Full time

Job summary

PacBio in the United States is seeking a Scientist, Biochemistry I or II to join the development and manufacturing team, focusing on commercialization of sequencing platforms. You will produce recombinant proteins per specifications and work in an ISO environment with cross-functional collaboration.

The role involves developing robust protein manufacturing processes, managing production orders, QC testing, and equipment qualification.

Qualifications

• MSc degree in Biochemistry, Protein Chemistry, Molecular Biology, or related scientific discipline.
• 5+ years of experience in the Life Sciences industry.
• Experience of minimum of 3 years in recombinant protein production, preferably with DNA polymerases.
• Experience working with affinity chromatography, IEX, HIC, and SEC, preferably for recombinant protein from bacterial expression system.
• Substantial experience with automated chromatography stations such as AKTA systems.
• Experience in analytical methodologies for protein characterization including HPLC, enzyme kinetics, protein quantification, spectrophotometer, SDS-PAGE.
• Experience in formulation and filtration techniques, such as TFF.
• Team player with the ability to take initiative in a fast-paced environment.
• Excellent interpersonal, written, and verbal communication skills.

Responsibilities

• Design and execute studies to develop and improve robustness of protein manufacturing processes
• Process protein production orders and execute reagent manufacturing activities in a timely manner
• Maintain records and production environment in compliance with quality standards
• Conduct troubleshooting on issues which arise during routine production
• Maintain, qualify, and validate equipment as appropriate
• Perform quality control tests
• Assist in inventory management and ordering materials
• Collaborate cross-functionally to ensure on-time completion of production builds
• Conduct development and technology transfer of reagent manufacturing processes and documentation
• Conduct new process development and transfer to production

Skills

Protein production experience

Analytical testing & QC

Troubleshooting & problem solving

Teamwork & collaboration

Written & verbal communication

Education

MSc degree in Biochemistry, Protein Chemistry, Molecular Biology, or related scientific discipline

Tools

AKTA chromatography systems

Affinity chromatography

IEX

HIC

SEC

HPLC

SDS-PAGE

enzyme kinetics

protein quantification

spectrophotometer

TFF

Job description

Scientist, Biochemistry I or II PacBio (NASDAQ: PACB) is a premier life science technology company that designs, develops, and manufactures advanced sequencing solutions to help scientists and clinical researchers resolve genetically complex problems. Our mission is to enable the promise of genomics to better human health. Genomics is core to all biological processes, and our advanced genomics tools provide scientists and clinical researchers the insights to better understand biology and health. We are now entering the century of biology and genomics is at the heart of the next revolution. Become part of the new paradigm in gene sequencing and help shape the future of genomic study by joining the PacBio team.

Position Summary:

This position will be part of development and manufacturing team to assist commercialization of sequencing platforms. They will be responsible for production of recombinant proteins conforming to product specifications. The ideal candidate would have broad knowledge in protein chemistry/molecular biology, and extensive experience in manufacturing protein products under ISO environment. They will be familiar with analytical tools used for characterization of enzymes, and skilled in troubleshooting and developing corrective solutions. The candidate must have strong collaborative and teamwork attributes.

Responsibilities:

• Design and execute studies to develop and improve robustness of protein manufacturing processes
• Process protein production orders and execute reagent manufacturing activities in a timely manner
• Maintain records and production environment in compliance with quality standards
• Conduct troubleshooting on issues which arise during routine production
• Maintain, qualify, and validate equipment as appropriate
• Perform quality control tests
• Assist in inventory management and ordering materials
• Collaborate cross-functionally to ensure on-time completion of production builds
• Conduct development and technology transfer of reagent manufacturing processes and documentation
• Conduct new process development and transfer to production

Required Qualifications:

• A minimum of MSc degree in Biochemistry, Protein Chemistry, Molecular Biology, or related scientific discipline
• A minimum of 5 years of experience in the Life Sciences industry
• Experience of minimum of 3 years in recombinant protein production, preferably with DNA polymerases
• Experience working with affinity chromatography, IEX, HIC, and SEC, preferably for recombinant protein from bacterial expression system
• Substantial experience with automated chromatography stations such as AKTA systems
• Experience in analytical methodologies for protein characterization including HPLC, enzyme kinetics, protein quantification, spectrophotometer, SDS-PAGE
• Experience in formulation and filtration techniques, such as TFF
• Team player with the ability to take initiative in a fast-paced environment
• Excellent interpersonal, written, and verbal communication skills

Preferred Experience:

• Experience in PLM and ERP systems
• Experience in ISO 9001 and 13485 regulated environments
• Knowledge of Next-Generation Sequencing

Candidates must have current authorization to work in the United States without the need for present or future sponsorship.

This role is required to be 100% onsite. You may be required from time to time to visit and work at PacBio locations and for such times as the Company considers necessary for the proper performance of your duties.

All listed tasks and responsibilities are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional tasks and responsibilities.

All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation.

#LI-Onsite Salary Range:

$97,400.00 - $168,000.00

Visit our following pages for more information on: FAQs Benefits Culture Equal Opportunity Employment At PacBio, we’re all on a mission to enable the promise of genomics to better human health. It’s what fuels us every day. Our team is passionate about catalyzing scientists pursuing biological discoveries, and we’re looking for exceptional individuals like you to join us. If you’re interested at being at the intersection where health and technology come together, then consider joining our team. We look forward to meeting you.

CORE VALUES:

• BE CURIOUS. Our future depends on it.
• DELIGHT OUR CUSTOMERS. We strive to get it right every time.
• TAKE ACTION. We move fast and take calculated risks.
• EXECUTION MATTERS. Our customers rely on us.
• WORK TOGETHER. We care deeply about each other.