Senior Scientist, Materials and Biophysical Characterization

Merck; Rahway (NJ); On-site; USD 117,000 - 184,000; Full time

Job summary

Merck is seeking a Senior Scientist in biophysical/biotherapeutics characterization to advance the CMC program. You will develop and apply biophysical and particle analysis tools, collaborating across formulation, process, and device teams to strengthen drug substance and product quality.

The role offers opportunities to publish, present at conferences, and contribute to regulatory documentation while growing within a diverse, collaborative environment.

Qualifications

• PhD with 0–4 years of industry experience or MS with 4–8 years of industry experience.
• Experience in the analysis of biologics, protein/peptide stability and interactions.
• Hands-on biophysical characterization of proteins/peptides using listed techniques.
• Understanding protein aggregation mechanisms and analytical method links.
• Strong written and oral communication; ability to work cross-functionally.

Responsibilities

• Develop and implement biophysical and particle characterization tools for a biotherapeutics pipeline.
• Collaborate with process, formulation and device teams as part of the CMC development group.
• Author technical reports and regulatory documents; present data to stakeholders.
• Publish research findings and present at scientific conferences; lead project work.

Education

Ph.D. in Biophysics/ Biochemistry/ Chemistry/ Chemical Engineering/ Biomedical Engineering/ Pharmaceutical Sciences or related

M.S. in Biophysics/ Biochemistry/ Chemistry/ Chemical Engineering/ Biomedical Engineering/ Pharmaceutical Sciences or related

Tools

Circular Dichroism (CD)

Infrared Spectroscopy (IR)

Differential Scanning Calorimetry (DSC)

Analytical Ultracentrifugation (AUC)

Dynamic Light Scattering (DLS)

Job description

Job Description

The Materials and Biophysical Characterization group in the Pharmaceutical Analysis and Digital Technologies organization is seeking a highly self-motivated and innovative scientist with deep knowledge and problem-solving skills in biotherapeutics characterization. The Materials and Biophysical Characterization team is responsible for building the mechanistic understanding of the interplay between formulation composition, stability, device, and process to ensure robustness and quality of drug substances and drug products in the biotherapeutics pipeline.

The Materials and Biophysical Characterization group in the Pharmaceutical Analysis and Digital Technologies organization is seeking a highly self-motivated and innovative scientist with deep knowledge and problem-solving skills in biotherapeutics characterization. The Materials and Biophysical Characterization team is responsible for building the mechanistic understanding of the interplay between formulation composition, stability, device, and process to ensure robustness and quality of drug substances and drug products in the biotherapeutics pipeline. As a Senior Scientist, you will be contributing to projects in a biotherapeutics pipeline by developing and implementing biophysical and particle characterization tools and collaborating with process, formulation and device functions as part of the CMC development team. You are expected to use your scientific expertise to find creative solutions to challenging problems which require deep analytical insight and critical thinking. Additional responsibilities include authoring technical reports and regulatory documents, presenting technical data, and project management. You will have the opportunity to conduct independent research, publish research findings, present at scientific conferences, and engage with various external scientific societies/organizations. This is an excellent growth and learning opportunity to work in an exciting, collaborative environment with a wide array of scientists from different divisions and make significant contributions towards our life-saving medicines.

Education Minimum Requirement

• Ph.D. in Biophysics, Biochemistry, Chemistry, Chemical Engineering, Biomedical Engineering, Pharmaceutical Sciences or related discipline with 0-4 years of relevant industry experience. Ph.D. candidates with expected degree conferment by Fall 2026 will be considered.
• OR M.S. in Biophysics, Biochemistry, Chemistry, Chemical Engineering, Biomedical Engineering, Pharmaceutical Sciences or related discipline with 4-8 years of relevant industry experience.

Required Experience And Skills

• Experience in the analysis of biologics, protein/peptide stability, protein-protein interactions
• Hands-on experience in biophysical characterization of proteins and/or peptides (e.g. Circular Dichroism (CD), Infrared Spectroscopy (IR), Differential Scanning Calorimetry (DSC), Analytical Ultracentrifugation (AUC), Dynamic Light Scattering (DLS))
• Understanding of protein aggregation mechanisms and link between analytical methodologies for analysis
• Ability to deliver complex objectives under aggressive timelines in a rapidly changing environment
• Demonstrated ability for taking initiative, creativity, and innovative problem solving.
• A strong team player with excellent oral and written communication skills; ability to work both independently and cross-functionally

Desired Experience And Skills

• Experience with characterization of lyophilized protein formulations
• Experience with biological formulation development and analytical method development.
• Experience with various biologics modalities including peptides, mAbs, ADC, fusion proteins
• Experience with characterization of protein-interface interactions (e.g. interfacial rheology, QCMD)
• Experience with subvisible and submicron particle characterization tools (e.g. flow imaging microscopy, backgrounded membrane imaging (BMI), flow cytometry)

Required Skills

Analytical Method Development, Bioanalytical Analysis, Biologics, Biophysics, Biotherapeutics, Peptides, Pharmaceutical Sciences, Protein Analysis, Protein Characterization

US And Puerto Rico Residents Only

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities.

We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively.

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The salary range for this role is

$117,000.00 - $184,200.00

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.

San Francisco Residents Only:

We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance.

Los Angeles Residents Only:

We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance.

Employee Status

Regular

Relocation

Domestic

VISA Sponsorship

No

Travel Requirements

No Travel Required

Flexible Work Arrangements

Not Applicable

Shift

1st - Day

Valid Driving License

No

Hazardous Material(s)

N/A

Job Posting End Date

09/17/2026

• A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Requisition ID:

R416475