Scientist, Antibody Conjugation

Alnylam Switzerland GmbH; Cambridge (MA); On-site; USD 110,400 - 165,600; Full time

Benefits offered by this job

Medical, dental, and vision coverage

Life and disability insurance

401(k) with company match

Job summary

Alnylam Switzerland GmbH is looking for a Scientist to join their Protein Sciences group in Cambridge, MA. The successful candidate will contribute to antibody conjugation efforts and must have a PhD along with a strong understanding of antibody conjugation chemistries.

The role includes performing chemical reactions, optimizing methods, and working with cross-functional teams. A base salary range of $110,400 - $165,600 is offered, along with a robust benefits package.

Qualifications

• Strong understanding of antibody conjugation methods is essential.
• Experience preparing and analyzing antibody-drug conjugates needed.
• Detail-oriented, self-motivated, and able to handle multiple projects.

Responsibilities

• Perform chemical reactions to assemble antibody-oligonucleotide conjugates.
• Optimize reactions and purification methods to improve yields.
• Communicate experimental plans and data effectively to teams.

Skills

Antibody conjugation chemistries

Analytical techniques (IEX, HIC, SEC, mass spec)

Pharmaceutical or biotechnology experience

Effective communication skills

Education

PhD degree

Tools

Agilent software

AKTA software

PowerPoint software

Job description

## Scientist, Antibody ConjugationUnited StatesApply NowFind out how well you match with this jobJob ID3282This role is considered:On-Site**Overview**We are seeking a Scientist to join our Protein Sciences group to help with our antibody conjugation efforts. The candidate must be independent, goal oriented, technically competent, and able to work efficiently across multiple projects. We are searching for enthusiastic, innovative, and highly motivated individuals, with a scientific background in antibody-drug conjugates including the assembly, purification, and analysis of these molecules.This position is **onsite**and will be primarily located in Cambridge, MA. **Key Responsibilities*** Perform chemical reactions to assemble antibody-oligonucleotide conjugates using various conjugation handles, linkers, and antibody formats (IgG, Fab, scFv, bispecific)* Utilize multiple strategies for stochastic and site-specific conjugation* Optimize reactions and purification methods to improve yields and efficiency ranging from mg to gram scale* Independently troubleshoot conjugation reactions for improved yields and processes* Analyze conjugates using all relevant techniques (IEX, HIC, SEC, SDS-PAGE, mass spec, UV-Vis)* Understanding of antibody design and cloning is nice to have* Understanding of antibody ligand/target validation using BLI and SPR for kinetic analysis is nice to have* Drive automation for high-throughput conjugation at various scales* Work closely with biology teams to plan studies and generate materials on time for multiple projects* Proper electronic notebook record keeping with high attention to detail* Communication of experimental plans and data to multiple cross-functional scientific teams* Work closely with biologists, chemists, and pharmacologists to contribute to the strategic direction of research programs across multiple therapeutic modalities**Qualifications*** The candidate should have a PhD degree with 0-3 years of relevant experience* Strong understanding of antibody conjugation chemistries with both stochastic and site-specific techniques* Strong understanding of modern ADC chemistry and linker design highly preferred* Hands on experiences with preparing antibody-drug conjugates and analyzing them using multiple methods (IEX, HIC, SEC, mass spec)* 0-2 years of pharmaceutical or biotechnology industry experience is preferred* Experience with Agilent and AKTA software* Experience with recombinant protein analysis (affinity, size exclusion, reverse phase, hydrophobic interaction, ion exchange chromatography, SDS-PAGE, and UV-VIS spectroscopy)* Experience with SPR and/or Octet binding experiments is nice to have* Passionate about driving his or her projects to independently contribute to research directions and solve challenging issues* Detail oriented, self-motivated, and comfortable working with highly technical projects* Ability to work on multiple projects simultaneously and deliver conclusive results* Highly adaptable and responsive to new priorities in a fast-paced environment* Ability to train and supervise associate scientists in the laboratory* Effective written and oral communication skills* Experience with ELN record keeping* Experience preparing and presenting using PowerPoint software* Team oriented with strong work ethic#LI-JR1**U.S. Pay Range****$110,400.00 - $165,600.00**The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.*Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers*