SAP S/4HANA Manufacturing Lead - GMP-Driven Transformation

ProStaff Workforce Solutions; Billerica (MA); On-site; USD 120,000 - 160,000; Full time

Job summary

ProStaff Workforce Solutions in Massachusetts seeks a hands-on SAP S/4HANA Manufacturing Business Process Lead to support a major pharmaceutical manufacturing transformation in Billerica. You will own and optimize drug product manufacturing operations and drive SAP S/4HANA rollout on the shop floor.

The role requires GMP/GxP-compliant process design, cross-functional collaboration with Quality, IT, and Supply Chain, and hands-on testing, UAT, go-live, and hypercare to ensure continuous

Qualifications

• Bachelor’s degree in Pharmacy, Chemical Engineering, or Industrial Engineering.
• 5+ years of experience in Pharma, Medical Device manufacturing, or relevant experience.
• SAP S/4HANA experience within manufacturing environments.
• Experience with UAT, testing, go-live, cutover, hypercare, or process design activities.
• Experience with Production Planning, MRP, Process Orders, Production Orders, BOMs, Routings, and Master Data.
• Strong GMP/GxP-regulated manufacturing experience preferred.
• Experience with MES, EBR, or LIMS as part of manufacturing operations, including integration experience, is a plus; SAP expertise is the primary focus.

Responsibilities

• Lead design, mapping, and optimization of manufacturing processes in consultation with global process owners.
• Work with Digital/IT to translate operational requirements into SAP S/4HANA configuration.
• Validate master data from an operation and GMP perspective.
• Ensure GMP/GxP and data integrity compliance in daily manufacturing execution.
• Lead FIT–GAP, testing, UAT to ensure operational readiness and continuity of manufacturing execution and integration validation.
• Train operators, update SOPs, support hypercare to ensure stable and compliant manufacturing operations.
• Track KPIs (safety, quality, delivery, cost), and drive continuous improvement initiatives.
• Liaise with Quality, Supply Chain, Engineering, and IT teams to support effective manufacturing operations.

Job description

ProStaff Workforce Solutions in Massachusetts seeks a hands-on SAP S/4HANA Manufacturing Business Process Lead to support a major pharmaceutical manufacturing transformation in Billerica. You will own and optimize drug product manufacturing operations and drive SAP S/4HANA rollout on the shop floor.

The role requires GMP/GxP-compliant process design, cross-functional collaboration with Quality, IT, and Supply Chain, and hands-on testing, UAT, go-live, and hypercare to ensure continuous