SAP S/4HANA Manufacturing Business Process Lead

Prostaffworkforce; Billerica (MA); On-site; USD 120,000 - 160,000; Full time

Job summary

Prostaffworkforce seeks an hands-on SAP S/4HANA Manufacturing Business Process Lead to support a major pharma manufacturing transformation in Billerica, MA. The role bridges Operations and Digital Transformation, driving process design and system configuration on SAP S/4HANA within a regulated environment.

The candidate will own manufacturing operations optimization, lead FIT–GAP, UAT, and go-live activities, and collaborate with Quality, Supply Chain, Engineering, and IT to ensure compliant,

Qualifications

• Bachelor’s degree in Pharmacy, Chemical Engineering, or Industrial Engineering.
• 5+ years in Pharma/Medical Device manufacturing or related manufacturing.
• SAP S/4HANA experience in manufacturing settings.
• Experience with SAP PP, PP/PI, QM, and Production Planning.
• Experience supporting SAP implementations, upgrades, or transformations.

Responsibilities

• Lead design, mapping, and optimization of manufacturing processes with global process owners.
• Translate operational requirements into SAP S/4HANA configuration with IT teams.
• Validate master data from GMP perspective and ensure data integrity.
• Lead testing, UAT, go-live, and hypercare for manufacturing execution integration.
• Train operators, update SOPs, and drive continuous improvement KPIs.

Skills

SAP S/4HANA manufacturing

GMP/GxP

UAT/testing

Lean/Six Sigma

Cross-functional collaboration

Education

Bachelor’s degree in Pharmacy, Chemical Engineering, or Industrial Engineering

Tools

SAP PP

PP/PI

QM

Master Data management

Job description

SAP S/4HANA Manufacturing Business Process Lead

• Billerica, Massachusetts
• Manufacturing

We are seeking a hands‑on SAP S/4HANA Manufacturing Business Process Lead to support a major manufacturing transformation within a pharmaceutical manufacturing environment in Billerica, MA.

If you have experience with SAP S/4HANA in manufacturing and a background in pharmaceutical or other regulated manufacturing environments, we’d love to hear from you. play a key role in supporting a major manufacturing transformation.

Full-time Onsite

Direct Hire

Pay Rate: DoE

Job Summary

Hands‑on Manufacturing Lead to own and optimize drug product manufacturing operations at our Billerica formulation plant, while supporting the SAP S/4HANA rollout. This role bridges Operations and Digital Transformation, ensuring that manufacturing processes drive system design, adopted by the shop floor, and sustained in routine operations.

Area Of Responsibility

• Process Design &Operational Enablement:
• Lead design, mapping, and optimization of manufacturing processes in consultation with global process owners
• Work with Digital/IT to translate operational requirements into SAP S/4HANA configuration
• Validate master data from an operation and GMP perspective
• Ensure GMP/GxP and data integrity compliance in daily manufacturing execution
• Implementation & Testing:
• Lead FIT–GAP, testing, UAT to ensure operational readiness and continuity of manufacturing execution and integration validation
• Go-Live & Adoption:
• Train operators, update SOPs, support hypercare to ensure stable and compliant manufacturing operations
• Continuous Improvement:
• Track KPIs (safety, quality, delivery, cost), and drive continuous improvement initiatives.
• Cross-Functional Collaboration:
• Liaise with Quality, Supply Chain, Engineering, IT to support effective manufacturing operations
• Liaise with the central operations team for alignment of the process with SUN global template and site operational needs
• Behavioral Expectations
• Strong shop-floor engagement and ownership of day-to-day operational challenges
• Problem-solving mindset in a regulated manufacturing environment
• Other Duties as assigned

Work Conditions

• Office
• Controlled/manufacturing area

Physical Requirements

• Stand, walk, sit, use hands and fingers to handle or feel, reach with hands and arms, climb or balance, stoop, kneel, crouch or crawl, talk and hear
• Be able to multitask
• Operate computer/office machines

Travel Estimate: 20% of time in the initial phase

Required Qualifications

• Bachelor’s degree in Pharmacy, Chemical Engineering, or Industrial Engineering.
• 5+ years of experience in Pharma, Medical Device manufacturing, or relevant experience.
• SAP S/4HANA experience within manufacturing environments.
• SAP PP, PP/PI, QM, or Production Planning expertise.
• Experience supporting SAP implementations, upgrades, migrations, or transformation initiatives.
• Experience with UAT, testing, go-live, cutover, hypercare, or process design activities.
• Experience with Production Planning, MRP, Process Orders, Production Orders, BOMs, Routings, and Master Data.
• Experience partnering with Manufacturing, Quality, Supply Chain, Engineering, and IT teams.
• Strong GMP/GxP-regulated manufacturing experience preferred.
• Experience with MES, EBR, or LIMS as part of manufacturing operations, including integration experience, is a plus; SAP expertise is the primary focus.
• Project Management experience.
• Lean/Six Sigma experience preferred.

Our client offers a competitive compensation package as well as benefits package for eligible candidates.