Scientist, SPR

Stealth Startup; Boston (MA); On-site; USD 90,000 - 130,000; Full time

Benefits offered by this job

Collaborative, science-driven culture

Direct impact on project strategy and/

Job summary

Stealth Startup in Cambridge, MA is seeking a hands-on Scientist to lead biophysical and biochemical assay development for novel small molecule discovery. You will report to the Director of Biochemistry and collaborate with a small team on site in Cambridge.

The role emphasizes independent development and execution of rigorous experiments, combining strong technical skills with clear communication across disciplines.

Qualifications

• MS + 4 years industry experience or PhD in Biophysics, Biochemistry, Biology, Chemistry, or other relevant field
• 2-4 years of industry experience in small-molecule drug discovery
• Hands-on expertise with biophysical methodologies for RNA-small molecule interactions (SPR, BLI, TR-FRET)
• Experience translating mechanistic/structural insights into hit-to-lead strategies
• Proven ability to work independently and drive projects with minimal supervision
• Excellent communication and collaborative mindset
• Authorized to work in US

Responsibilities

• Own SPR workflows: establish, data generation, instrument maintenance, troubleshooting, external collaborations
• Propose and establish additional biophysical/biochemical assays to advance RNA-targeting discovery
• Document and maintain SOPs with timely electronic lab notebook entries
• Oversee CRO partners across assay design, execution, and troubleshooting

Skills

Independent worker

Strong communication

Collaborative mindset

Biophysical assay development

Education

MS or PhD in Biophysics/Biochemistry/Biology/Chemistry

Tools

SPR

BLI

TR-FRET

Job description

We are a seed stage biotech company focused on discovering modulators of the RNA lifecycle for undrugged disease drivers. We seek a creative and motivated Scientist with industry experience and a background in biophysical and biochemical assay development for novel small molecule discovery. You will report to the Director of Biochemistry and work closely with a small, collaborative team at our site in Cambridge, Massachusetts.

This role is hands-on and lab-focused, requiring independent development and execution of rigorous biophysical and biochemical experiments within an early-stage biotech environment. The successful candidate will combine strong experimental skills with the ability to communicate clearly and collaborate with scientists across multiple disciplines.

We were founded by academic leaders in RNA biology and are financed by The Column Group.

• Ownership of SPR: establish workflows, generate data, maintain our instrument, troubleshoot, manage external SPR efforts, and communicate progress and direction.
• Propose, evaluate, and establish additional biophysical and biochemical assays, approaches, and technologies to advance RNA-targeting discovery efforts.
• Document and maintain high-quality SOPs, including timely electronic lab notebook entries.
• Oversee CRO partners across assay design, execution, and troubleshooting.

Qualifications:

• MS + 4 years experience or PhD in Biophysics, Biochemistry, Biology, Chemistry, or other relevant field
• 2-4 years of industry experience in small-molecule drug discovery (biotech or pharma).
• Hands-on expertise with a diverse set of biophysical methodologies for interrogating interactions between RNA and small molecules (e.g., SPR, BLI, TR-FRET).
• Experience translating mechanistic and structural insights into practical strategies for optimizing and advancing hits to leads.
• Proven ability to work independently and drive projects with minimal supervision
• Excellent communication skills and collaborative mindset
• Authorized to work in US

Preferred:

• Experience in early-stage biotech environment(s)
• Track record of publications or patents in small-molecule drug discovery

What we offer:

• Collaborative, science-driven culture
• Direct impact on project strategy and company direction