Researcher 1- Neurological Surgery

Ohio State University; North Carolina; On-site; USD 60,000 - 85,000; Full time

Job summary

Ohio State University’s Department of Medicine | Neurological Surgery seeks a Researcher 1 to plan, design, and manage in-vivo studies focused on translational CNS therapies, including AAV, liposomes, and mRNA nanoparticle approaches.

You will perform necropsies, tissue collection, histology, data analysis, and documentation for regulatory submissions, while maintaining GLP/IACUC compliance and supporting publication efforts.

Qualifications

• Experience with murine colony management: breeding, weaning, tagging, and humane euthanization.
• Proficient with necropsy techniques in small and large animals.
• Knowledge of GLP/IACUC compliance and regulatory requirements.

Responsibilities

• Plan, design, execute, and manage in-vivo research studies in translational CNS therapies.
• Perform necropsy and tissue collection; lead necropsy function and histology duties.
• Collect, analyze, and interpret data; maintain records for FDA submissions.
• Support preparation of research papers, proposals, and reports; assist PI with funding initiatives.

Skills

Murine models

In vivo techniques

Tissue collection

Data analysis

IACUC compliance

Job description

Job Title:

Researcher 1- Neurological Surgery

Department:

Medicine | Neurological Surgery

Responsibilities:

Research Associate who participates in planning, design, execution, and management of all in-vivo research studies and activities in a research laboratory investigating translational pre-clinical studies in the development of AAV, drug-loaded liposomes, mRNA-based nanoparticles-based gene therapies for central nervous system disorders such as Parkinson's disease, Huntington's disease, AADC deficiency, Alzheimer's disease, lysosomal storage disorders, hearing loss, and depression in the Department of Neurological Surgery; participates in the execution of ongoing research projects; proficient in specialized necropsy techniques in small and large animals with the ability to lead necropsy function in the lab; leads efficient and high-quality sample collection, processing, tissue preservation and tissue trimming according to study protocols; assists with histology duties such as tissue processing, embedding, frozen sections, sorting, cutting, filing, reagent preparation, special stains, and staining slides of tissue samples; collects, analyzes, and interprets research data; assists in establishment of controls, criteria and research standards; collects and maintains preclinical study data effectively and efficiently for FDA submission; creates and keeps detailed and organized records of all in-vivo research activities across various studies; has extensive knowledge in murine animal model experimentation, including injections (intramuscular, intraperitoneal, intravenous (tail vein and RO)), as well as blood collection techniques including cardiac puncture and cheek bleed, and tissue collection; murine colony management including breeding and weening, mice tagging identification, monthly cage counting, record keeping, and euthanization; maintains accuracy of and compliance to IACUC protocol and ensures GLP conditions in IND-enabling in-vivo research studies; works closely with laboratory veterinarians and IACUC committee and staff to efficiently update the IACUC protocol as new studies are proposed and assists collaborators with IACUC protocol creation and adherence; manages lab spaces in accordance with IACUC and EHS regulations and leads IACUC and controlled substance inspections; assists in the preparation of research papers and manuscripts for publication and presentation at national and conferences and workshops, and in the writing of project reports, articles, and other documents; assists principal investigator in the preparation of proposals to obtain new or renewal of extramural funding in support of research; provides updates to PI and laboratory manager on progress of research.

Additional Information:

• Location: Pelotonia Research Center (1040)
• Position Type: Regular
• Scheduled Hours: 40
• Shift: First Shift

Final candidates are subject to successful completion of a background check. A drug screen or physical may be required during the post offer process.

The university is an equal opportunity employer, including veterans and disability.