Research Specialist: Kidney Genetics, Genomics, and Advanced Models Laboratory

University of California, San Francisco; San Francisco (CA); On-site; USD 63,500 - 194,800; Full time

Job summary

The Kidney Genetics, Genomics, and Advanced Models Laboratory at UCSF’s Mission Bay campus is seeking a research specialist with expertise in human stem cell culture and organoid development to advance iPSC‑based kidney disease models.

The role involves engineering iPSCs, performing CRISPR screens, and collaborating across disciplines. Strong emphasis on independent work and career development in a multidisciplinary team is expected.

Qualifications

• Must possess significant experience with iPSC culture, generation of iPSC‑derived cell types or organoids, and immunofluorescence.
• Experience with genome engineering of in‑vitro cell types, scRNA‑sequencing, and CRISPR screens is preferred.
• Assistant rank requires a master’s degree (or equivalent) related to the focus area or a bachelor’s with 3+ years of relevant experience.
• Associate rank requires a master’s degree or 5–10 years of experience with scholarly record.

Responsibilities

• iPSC‑derived Kidney Organoid Research: conduct kidney disease research using iPSC‑derived organoids and enhance ability to run genetic/small molecule screens with organoids.
• Genetically engineer iPSCs to enable screens in organoids.
• CRISPR screens: perform CRISPR screens in kidney organoids.

Skills

iPSC culture

organoid models

immunofluorescence

genome engineering

scRNA-seq

CRISPR screens

collaboration

communication

Education

Master’s degree or equivalent

Bachelor’s degree with 3+ years relevant experience

Master’s degree with 5+ years experience

Job description

Research Specialist: Kidney Genetics, Genomics, and Advanced Models Laboratory

The Kidney Genetics, Genomics, and Advanced Models Laboratory at the Mission Bay campus of UCSF is recruiting individuals with expertise in human stem cell culture and in vitro cell model development to serve as a research specialist.

Responsibilities

• iPSC‑derived Kidney Organoid Research: The research specialist will conduct kidney disease research using iPSC‑derived kidney organoids. They will improve kidney organoids as models of human kidney disease and enhance ability to conduct genetic and small molecule screens in kidney organoids. Characterization of organoids will be performed using scRNA‑seq and immunofluorescence.
• Genetically engineer iPSCs: The research specialist will genetically engineer iPSCs to enable genetic and small molecule screens in kidney organoids.
• CRISPR screens: The research specialist will conduct CRISPR screens in kidney organoids.

Candidates will be expected to work independently and in a collaborative multidisciplinary team. Opportunities for career development will be provided and encouraged. The candidate will report to Gabriel Loeb, MD, PhD, the Principal Investigator of the Kidney Genetics, Genomics, and Advanced Models Laboratory.

Qualifications

• Must possess significant experience with iPSC culture, generation of iPSC‑derived cell types or organoids, and immunofluorescence. Experience with genome engineering of in‑vitro cell types, scRNA‑sequencing, and CRISPR screens is preferred.
• Assistant rank must possess a master’s degree (or equivalent degree) related to the area of focus or a baccalaureate degree (or equivalent degree) with three or more years of experience demonstrating expertise in the relevant specialization.
• Associate rank must possess a master’s degree (or equivalent degree) related to the area of focus or five to ten years of experience demonstrating expertise in the relevant specialization. Associate Specialists are normally expected to have a record of academic accomplishments, including contributions to published or in‑press research in the field and a demonstrated record of University and/or public service.
• Full Specialist rank must possess a terminal degree (or equivalent degree) related to the area of focus or ten or more years of experience demonstrating expertise in the relevant specialization. Specialists at full rank are normally expected to have a significant record of academic accomplishments, including contributions to published or in‑press research in the field, professional recognition in the field, and a demonstrated record of University and/or public service.
• Demonstrated ability to organize, interpret, evaluate, and present research findings in a variety of formats including manuscripts, grant proposals, reports to stakeholders, and oral presentations, and facilitate collaborative and instructional scientific interactions within laboratory and discussion settings.
• Ability to think creatively and independently on concepts requiring advanced analytical skills.
• Interpersonal skills and ability to work with diverse groups to achieve results.
• Ability to work collaboratively with internal and external peers.

Mandatory Document Requirements

• Curriculum Vitae – must clearly list current and/or pending qualifications (e.g., board eligibility/certification, medical licensure, etc.).
• Cover Letter (Optional)
• Statement of Research (Optional)
• Statement of Teaching (Optional)

Please apply online at https://aprecruit.ucsf.edu/JPF05621. Applicants’ materials must list current and/or pending qualifications upon submission.

See Table 24B for the salary range for this position. A reasonable estimate for this position is $63,500–$194,800.

The University of California is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected status under state or federal law.

UCSF is committed to welcoming and serving all people, honoring the dignity of every individual without preference or prejudice, in support of its public mission and in alignment with our PRIDE values and Principles of Community.

As a condition of employment, the finalist will be required to disclose if they are subject to any final administrative or judicial decisions within the last seven years determining that they committed any misconduct. “Misconduct” means any violation of the policies or laws governing conduct at the applicant’s previous place of employment, including, but not limited to, violations of policies or laws prohibiting sexual harassment, sexual assault, or other forms of harassment, or discrimination, as defined by the employer.

• UC Sexual Violence and Sexual Harassment Policy
• UC Anti‑Discrimination Policy
• APM – 035: Affithive Action and Nondiscrimination in Employment

San Francisco, CA