Research Scientist - Protein Science and Technology

ICON Strategic Solutions

Wilmington (DE)

On-site

USD 65,000 - 85,000

Full time

14 days+

Get more replies from employers

Send a job-specific resume in minutes.

Benefits offered by this job

Annual leave entitlements

Health insurance offerings

Retirement planning

Employee Assistance Programme

Life assurance

Flexible voluntary benefits

Job summary

A leading clinical research organization is seeking a Research Scientist to join their structural biology team in Wilmington, DE. The role involves expressing, purifying, and characterizing recombinant proteins, with an emphasis on collaboration and innovative strategies. Ideal candidates will possess a BS/MS degree and have 2-3 years of relevant experience. This full-time position offers a comprehensive benefits package supporting work-life balance.

Qualifications

2-3 years of experience in recombinant protein production.
Experience with Cryo-EM and Crystallography is desirable.
Good communication skills.

Responsibilities

Express, purify, and characterize recombinant proteins.
Design and execute protocols for protein purification.
Analyze and report data to stakeholders.

Skills

Protein Expression

Protein Purification

Biophysical Characterization

Data Analysis

Team Collaboration

Troubleshooting

Education

BS/MS in relevant field

Job description

Research Scientist - Protein Science and Technology

As a Research Scientist you will be joining the world’s largest & most comprehensive clinical research organisation, powered by healthcare intelligence. We are looking for a motivated scientist with experience in recombinant protein production to join our structural biology team. In this role, you will be responsible for expressing, purifying, and characterizing recombinant proteins and complexes to support Cryo-EM and Crystallography studies.

What You Will Be Doing

Protein Expression: Transfection of plasmids into mammalian cells and cell line maintenance, generation of baculovirus and expression of proteins in Sf9 cells, expression of proteins in bacterial systems. Good experience expressing proteins is very important for this position.
Protein Purification: Design, optimize, and execute protocols for the purification of recombinant proteins using commonly applied chromatography techniques (e.g., affinity, ion exchange, size exclusion).
Biophysical Characterization: Perform biophysical characterization of purified proteins, including but not limited to analytical SEC, Differential Scanning Fluorimetry (DSF), Thermal Stability Assays.
Data Analysis & Reporting: Maintain detailed records of experimental designs, data, and results. Analyze and interpret data for presentation to key stakeholders.
Team Collaboration: Work closely with structural biology team to determine protein constructs with optimal stability and functionality.
Daily operations: Help the daily operations of the protein production team, maintaining a highly productive protein production laboratory, performing small- and large-scale expression and purification experiments, characterization of samples, and contributing to development of the lab.
Strategy development: As a team member, develop and implement short and long-term strategies to enhance protein production capabilities.
Vectors and cloning: Good understanding or experience with vectors and cloning strategies needed for protein expression in different cell systems.
Troubleshooting: Help troubleshooting recombinant protein expression to maximize protein yield.
Independent work: Ability to work independently (but under guidance) to deliver high quality purified protein samples and complexes for structural studies.
Workflows: Ability to efficiently and reproducibly follow established workflows.
Cryo-EM and Crystallography: Cryo-EM and Crystallography experience is highly desirable but not required.

You Are

BS/MS with a minimum of 2-3 years of experience.
Proven experience supporting drug discovery programs using structural biology and biochemistry is desirable.
Good communication and interpersonal skills.
Proven experience working with matrix teams.
Self-driven, creative and entrepreneurial with ability to support multiple programs simultaneously.
Office based in Wilmington, DE

What ICON Can Offer You

Our success depends on the quality of our people. That’s why we’ve made it a priority to build a diverse culture that rewards high performance and nurtures talent. In addition to your competitive salary, ICON offers a range of additional benefits. Our benefits are designed to be competitive within each country and are focused on well-being and work life balance opportunities for you and your family.

Various annual leave entitlements
A range of health insurance offerings to suit you and your family’s needs
Competitive retirement planning offerings to maximise savings and plan with confidence for the years ahead
Global Employee Assistance Programme, TELUS Health, offering 24-hour access to a global network of over 80,000 independent specialised professionals who are there to support you and your family’s well-being
Life assurance
Flexible country-specific optional benefits, including childcare vouchers, bike purchase schemes, discounted gym memberships, subsidised travel passes, health assessments, among others

Visit our careers website to read more about the benefits of working at ICON.

At ICON, inclusion & belonging are fundamental to our culture and values. We’re dedicated to providing an inclusive and accessible environment for all candidates. ICON is committed to providing a workplace free of discrimination and harassment. All qualified applicants will receive equal consideration for employment without regard to race, colour, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please let us know through the form below.

Interested in the role, but unsure if you meet all of the requirements? We would encourage you to apply regardless – there’s every chance you’re exactly what we’re looking for here at ICON whether it is for this or other roles.

Seniority level