Research Scientist - Hawse Lab

University of Pittsburgh; Pittsburgh (Allegheny County); On-site; USD 54,000 - 89,000; Full time

Job summary

University of Pittsburgh, Department of Immunology, invites applications for a Research Scientist to study signaling and T cell differentiation, focusing on Th17 biology in autoimmune disease models. The role combines in vitro cell culture with in vivo mouse experiments, data analysis, and manuscript preparation.

The successful candidate will lead experiments, train technicians and students, and contribute to grant proposals and scientific publications in a dynamic, collaborative lab at

Qualifications

• Ph.D. required with at least 5 years of relevant research experience.
• Experience with autoimmune disease models advantageous.
• Experience leading projects and publishing results.

Responsibilities

• Conduct independent scientific research from inception to presentation.
• Design and perform in vitro and in vivo experiments in autoimmune disease models.
• Isolate and culture naïve CD4 T cells from lymph nodes and spleens of mice.
• Prepare manuscripts, grant proposals, and presentations; train staff and students.

Skills

T cell culture

In vitro work

In vivo experiments

Data analysis

Education

Professional Doctorate Degree

Tools

RT-PCR

Western blot

Cell isolation

Mice handling

Job description

Job Description - Research Scientist - Hawse Lab (26005788)

Research Scientist - Hawse Lab

The Department of Immunology conducts exceptional and impactful research that uncovers new mechanisms and pathways of the immune system to translate discoveries to improve human health by combating disease, enhancing vaccination, and controlling cancer and autoimmunity; to incorporate and develop cutting‑edge technologies, including systems and computational approaches; and to train the next generation of immunologists in a collegial and dynamic research environment.

The University of Pittsburgh, Department of Immunology, is seeking a qualified Research Scientist, Ph.D. Required plus 5 years of work experience.

This position will focus on studying research projects concerning signaling and T cell differentiation. This position will conduct scientific research using a combination of both in vitro and in vivo methodologies to comprehensively investigate the underlying mechanisms involved in autoimmune disease development. The in vitro component of the study will focus on the isolation and culture of naïve CD4 T cells obtained from the lymph nodes and spleens of C57BL/6J mice. These cells will be cultured under Th17-polarizing conditions to promote their differentiation into Th17 cells. Th17 cells are a specialized subset of CD4+ T helper cells that have been extensively implicated in the pathogenesis and progression of various autoimmune disorders, making them a critical target for this investigation.

This position requires research experience designing and developing of in vitro and in vivo experiments in animal models of autoimmunity diseases. This position should have the technical skills such as primary cell culture (T cells), RT-PCR, western blot, and will perform the collection, interpretation, discussion and presentation of scientific data.

This position will prepare manuscripts, research grant proposals, research articles and publications, and give presentations on their research findings. This position will train Research Technicians, Postdoctoral Associates, Graduate Student Researchers and Pitt undergrad students.

These tasks require a skilled scientist who can independently work with minimum consultation with the principal investigator.

Job Summary

Conducts independent scientific research projects from inception to presentation. Prepares and crafts various documentations of research results into manuscripts, proposals, grant applications, and presentations. Trains undergraduates and research technicians. Manages laboratory policies and coordinates project development in collaboration with other specialists.

Essential Functions

• Perform cell isolation and culture of naïve CD4 T cells obtained from the lymph nodes and spleens of C57BL/6J mice.
• Must design and develop in vitro and in vivo experiments in animal models of autoimmunity diseases.

Physical Effort

Minimal

The University of Pittsburgh is an equal opportunity employer / disability / veteran.

Assignment Category Full-time regular

Job Classification Staff.Research Scientist

Job Family Research

Job Sub-Family Research Science

Campus Pittsburgh

Minimum Education Level Required Professional Doctorate Degree

Minimum Years of Experience Required 5

Will this position accept substitution in lieu of education or experience? No

Additional details about Required Licensure/Certification None

Work Schedule Monday - Friday, 8:30 a.m. - 5:00 p.m.

Work Arrangement On-Campus: Teams that work on campus, in an office, or in a lab.

Hiring Range $53,617 to $89,361 annual.

Relocation Offered No

Visa Sponsorship Provided Yes

Background Check For position finalists, employment with the University will require successful completion of a background check

Child Protection Clearances Not Applicable

The University of Pittsburgh is an equal opportunity employer / disability / veteran.