Research Scientist

Bristol Myers Squibb; Cambridge (MA); On-site; USD 55,000 - 69,000; Full time

Job summary

Bristol Myers Squibb is seeking a Scientist for a 7-month contract in the Oncology Research and Development team at Cambridge Crossing. The role is heavily wet-lab oriented, contributing to cancer biology research, target identification, and drug discovery.

You will collaborate with cross-functional teams including medicinal chemistry and bioinformatics to advance projects, analyze data, and prepare technical reports and publications.

Qualifications

• Bachelor's or Master's degree in Biological Sciences, Molecular Biology, Biochemistry, or related field
• Strong analytical and problem-solving skills with attention to detail and troubleshooting abilities
• Ability to work independently and as part of a collaborative team
• Excellent organizational skills with the ability to manage multiple tasks and deadlines
• Effective written and verbal communication skills

Responsibilities

• Conduct full-time laboratory-based research supporting target identification, oncology drug discovery and development.
• Execute molecular biology, cellular biology, and biochemical assays, including maintenance and manipulation of 2D and 3D cell cultures (spheroids and organoids).
• Perform lentiviral and nucleofection-based gene transfer and genome editing (CRISPR/Cas9, Cas12, shRNA/siRNA).
• Assess cell viability and cytotoxicity using IncuCyte, CellTiter-Glo, CyQUANT, and clonogenic assays.
• Conduct large-scale functional genetic and phenotypic screens.
• Execute RT-qPCR and western blot, and prepare samples for RNA-seq.
• Co-immunoprecipitation and other protein interaction studies; perform immunoassays (ELISA, MSD).
• Design, optimize, and troubleshoot complex cell-based assays; collaborate with cross-functional teams to advance project goals.

Skills

Analytical skills

Problem solving

Independent work

Team collaboration

Time management

Communication

Education

Bachelor's or Master's degree in Biological Sciences, Molecular Biology, Biochemistry, or related field

Tools

CRISPR/Cas9

Cas12

Lentiviral transduction

Organoid/3D culture techniques

RT-qPCR

Western blot

ELISA

MSD

IncuCyte

CellTiter-Glo

Job description

The candidate must be able to work onsite 5 days a week at Cambridge Crossing. 100% onsite.

There is a $20/day parking fee at Cambridge Crossing that is not reimbursed.

Position Overview:

We are seeking a motivated and talented Scientist to join our Oncology Research and Development team on a 7-months contract basis. This position is heavily focused on wet lab work, contributing to cutting-edge research projects aimed at understanding cancer biology, identifying novel drug targets, and developing new therapeutic approaches. The successful candidate will work in a collaborative and dynamic environment alongside leading scientists in the field of oncology.

Key Responsibilities:

• Conduct full time laboratory-based research supporting target identification, oncology drug discovery and development.
• Execute a variety of molecular biology, cellular biology, and biochemical assays, including:
• Maintenance and manipulation of 2D and 3D cell cultures, including spheroids and organoids.
• Lentiviral and nucleofection based gene transfer and genome editing.
• Target gene perturbation using CRISPR/Cas9 and Cas12, shRNA and siRNA.
• Cell viability and cytotoxicity assays using IncuCyte , Cell Titer-Glo, Cy QUANT and clonogenic assays.
• Large scale functional genetic and phenotypic screens.
• RT-qPCR and western blot, sample prepping for RNA-seq.
• Co-immunoprecipitation (coIP), and other protein interaction studies.
• ELISA, Meso Scale Discovery (MSD),and other immunoassays.
• Design, optimize, and troubleshoot complex cell-based assays to evaluate therapeutic candidates and understand cancer signaling pathways.
• Collaborate with cross-functional teams, including medicinal chemistry, bioinformatics, and in vivo pharmacology ,to advance project goals.
• Analyze and interpret experimental data, maintain accurate and detailed lab records, and present findings in team meetings.
• Contribute to the preparation of technical reports, publications, and presentations.

Qualifications:

• Bachelors or Masters degree in Biological Sciences, Molecular Biology, Biochemistry, or a related field with extensive and demonstrated track record of experience in conducting oncology research in an academic or industry setting.
• Strong analytical and problem-solving skills, with attention to detail and a capacity to troubleshoot experimental protocols.
• Ability to work independently and as part of a collaborative team.
• Excellent organizational skills, with the ability to manage multiple tasks and deadlines.
• Effective communication skills, both written and verbal.

Preferred Qualifications:

• Extensive experience with oncology research, cancer biology, and drug discovery processes.
• Experience with advanced techniques such as high-content imaging and flow cytometry.
• Proficiency in data analysis software (e.g., GraphPad Prism, Flow Jo) and familiarity with bioinformatic stools.