Research Scientist

Guidehouse Inc.; Bethesda (MD); On-site; USD 98,000 - 163,000; Full time

Benefits offered by this job

Insurance

Parental Leave

401k Plan

Tuition Reimbursement

Employee Assistance

Job summary

Guidehouse seeks a Research Scientist to independently support NIH project objectives in Bethesda, MD. This full-time role involves advanced immunology, molecular biology, and sequencing tasks across tissue samples and cell lines.

The ideal candidate has a Ph.D. or equivalent, 6+ years of research in molecular biology and immunology, and experience with mouse models and multi-omics analyses. NIH experience is preferred, and the team collaborates across core facilities.

Qualifications

• Ph.D. or M.D. in science, medicine, or related field.
• Minimum of SIX (6) years of research experience.
• Extensive experience in molecular biology, biochemistry, and immunology.
• Experience generating knockout mice and working with mouse models.
• Extensive experience with next generation sequencing methods (RNA-seq, scRNA-seq, ChIP-seq, ATAC-seq).
• Experience with flow cytometry, immunohistochemistry, and metabolomics.

Responsibilities

• Perform immunology and molecular biology techniques with animal and human cells/tissues.
• Conduct biochemical assays, immunoprecipitations, gels, and western blotting.
• Perform sequencing techniques for transcriptomics and epigenetic analyses.
• Immunofluorescence staining and functional analyses of tissue samples.
• Collaborate with cores (sequencing, mass spec, flow cytometry) as needed.
• Present research at international and national meetings.

Skills

Molecular biology

Immunology

Next-generation sequencing

Cell culture

Project management

Scientific writing

Education

Ph.D. or M.D. in science/medicine

Job description

Job Family :

Scientist

Travel Required :

Up to 10%

Clearance Required :

Ability to Obtain Public Trust

What You Will Do :

We are currently searching for a Research Scientist. This role will independently provide support services to satisfy the overall operational objectives of the National Heart, Lung, and Blood Institute. The primary objective is to provide services and deliverables through performance of support services. This is a full-time opportunity located in Bethesda, MD.

• Perform a wide array of immunology and molecular biological techniques with animal and human cells/tissues.
• Perform a variety of biochemical assays, immuno-precipitations, polyacrylamide gel electrophoresis and western blotting.
• Perform a range of next generation sequencing techniques, including for transcriptomics and epigenetic analyses.
• Perform immunofluorescence staining and functional analyses of tissue samples.
• Work with the sequencing, mass spectrometry, flow cytometry, and other cores as needed.
• Maintain mouse lines (breeding, genotyping).
• Present research at international and national research meetings.
• Conduct and help direct independent research projects of high priority for the laboratory.
• Assist the Lab Chief in the creating/preparing documents required by the Lab Chief's scientific activities (e.g., CRADAs, Material Transfer Agreements, Patent Applications, Animal Protocols, BSC review).
• Review, edit, and write drafts of papers, posters and manuscripts produced within the laboratory for consistency of the research agenda, adherence to any applicable scientific policies, and clarity of presentation of data and other scientific information.
• Act as a scientific consultant, technical expert, and collaborator for IRTA fellows, Visiting Fellows, and others in the lab as needed.

What You Will Need :

• Ph.D. or M.D. or other appropriate doctoral degree in science, medicine, or related field
• Minimum of SIX (6) years of research experience in science, medicine, or related fields.
• Extensive experience in molecular biology, biochemistry, and immunology research, including experience in immune cell development and function.
• Experience generating knockout mice, conditional knockout mice, and extensive experience working with mice/mouse models.
• Extensive experience related to next generation sequencing methods and analyses (e.g., RNA-seq, scRNA-seq, ChIP-seq, ATAC-seq, Hi-C, HiChIP, PCA, UMAP, tSNE).
• Experience with advanced molecular biology techniques (e.g., ChIP, co-IP, advanced cloning techniques, western blotting, Northern blotting, Southern blotting, Q-PCR).
• Experience with flow cytometry, immunohistochemistry, and metabolomics.
• Extensive experience in cell culture and/or extensive knowledge of cell biology.
• Ability to manage and coordinate high-priority short- and long-term projects and studies in a fast-paced environment.

What Would Be Nice To Have :

• Previous experience with NIH preferred.
• Proficient in Microsoft Office and PowerPoint

The annual salary range for this position is $98,000.00-$163,000.00. Compensation decisions depend on a wide range of factors, including but not limited to skill sets, experience and training, security clearances, licensure and certifications, and other business and organizational needs.

What We Offer

Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.

Benefits include:

• Medical, Rx, Dental & Vision Insurance
• Personal and Family Sick Time & Company Paid Holidays
• Parental Leave
• 401(k) Retirement Plan
• Group Term Life and Travel Assistance
• Voluntary Life and AD&D Insurance
• Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts
• Transit and Parking Commuter Benefits
• Short-Term & Long-Term Disability
• Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities
• Employee Referral Program
• Corporate Sponsored Events & Community Outreach
• Care.com annual membership
• Employee Assistance Program
• Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)

Position may be eligible for a discretionary variable incentive bonus

About Guidehouse

Guidehouse is an Equal Opportunity Employer-Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation.

Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco.