Research Lab Specialist Senior/Intermediate/Associate

University Of Michigan; Ann Arbor (MI); Hybrid; USD 65,000 - 85,000; Full time

Job summary

Join a leading research team at a prestigious institution focused on lung biology and disease. The position offers opportunities to lead projects, develop skills in advanced techniques, and contribute to significant discoveries in the field. Ideal for candidates with a strong background in cell biology and a passion for research.

Benefits

Excellent medical, dental and vision coverage

2:1 Match on retirement savings

Qualifications

• PhD or Master's Degree required for Research Specialist Senior.
• 5-6 years of experience in a related field for Research Specialist Senior.
• At least one first authored manuscript required for candidates with a PhD.

Responsibilities

• Lead role in the development and implementation of the research program.
• Work closely with the PI on research related to lung biology.
• Opportunities to learn cutting-edge techniques.

Skills

Organizational Skills

Attention to Detail

Flexibility

Education

PhD

Master's Degree

Bachelor's Degree

Tools

Microscopy

RNA/qPCR

Western Blotting

Flow Cytometry

Job description

A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.

Job Summary

Our lab is interested in understanding the mechanisms by which the lung epithelium responds to injury. We study mechanisms of injury/inflammation and regeneration after injury. Epithelial injury and a failure of epithelial regeneration is thought to drive the development of lung diseases such as ARDS (including COVID-19), fibrosis, and emphysema. Specifically, we are exploring the mechanisms underlying proliferation and differentiation of alveolar epithelial progenitor or stem cells. We have identified ?-catenin, HIF, and TGF? signaling as important drivers. We also study the epithelial inflammatory and host defense responses to bacterial and viral infection, specifically epithelial-immune cell crosstalk. We use mouse and cell culture models to study mechanisms. The mouse work involves lineage tracing and inducible cell-specific gene deficient mice, and primary epithelial cell culture/organoid work allows us to further dissect mechanism. We use confocal imaging, immunostaining, fluorescence in situ hybridization (FISH), single cell RNA sequencing, proteomics, and flow assisted cytometry sorting (FACS). We aim to address important questions and make novel discoveries that significantly enhance out understanding of lung biology and disease. We hope that our discoveries may ultimately lead to the development of therapies for infectious, inflammatory, and fibrotic lung diseases.

Mission Statement

Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally. Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society.

Why Join Michigan Medicine?

Michigan Medicine is one of the largest health care complexes in the world and has been the site of many groundbreaking medical and technological advancements since the opening of the U-M Medical School in 1850. Michigan Medicine is comprised of over 30,000employees and our vision is to attract, inspire, and develop outstanding people in medicine, sciences, and healthcare to become one of the world’s most distinguished academic health systems. In some way, great or small, every person here helps to advance this world-class institution. Work at Michigan Medicine and become a victor for the greater good.

What Benefits can you Look Forward to?

• Excellent medical, dental and vision coverage effective on your very first day
• 2:1 Match on retirement savings

Responsibilities*

The staff scientist will be expected to take a leading role and work closely with the PI in the development and implementation of this research program. A PhD (completed or near completion) or MS or BS with significant experience in cell biology, developmental biology, immunology, physiology, or related field is required. Outstanding organizational skills, attention to detail, ability to work hard and be flexible in a fast-paced environment, and ability to get along with other lab members are important. Prior experience with rodents, cell culture, microscopy, RNA/qPCR, western blotting, computational biology, and/or flow cytometry would be helpful. At least one first authored manuscript in a peer-reviewed journal is required for candidates with a PhD. Candidates interested in either leading their own projects or supporting projects of other team members are encouraged to apply.

Excellent opportunity for individuals interested in studying stem cells and tissue regeneration as well as immune-epithelial crosstalk. Projects range from basic mechanistic to translational. Opportunities to learn cutting-edge techniques, including organoid culture and scRNAseq. Opportunities for career development, including manuscript and grant writing and oral presentation, mentorship, attending international conferences, interacting with renowned scientists who are collaborators.

Required Qualifications*

• Research Specialist Senior: PhD or Master's Degree is required. 5-6 years of experience in a related field.
• Research Specialist Intermediate: Bachelor's Degree is required. 4-5 years of experience in a related field.
• Research Specialist Associate: Bachelor's Degree is required. 2-3 years of experience in a related field.

Modes of Work

Positions that are eligible for hybrid or mobile/remote work mode are at the discretion of the hiring department. Work agreements are reviewed annually at a minimum and are subject to change at any time, and for any reason, throughout the course of employment. Learn more about the work modes .

Underfill Statement

This position may be underfilled at a lower classification depending on the qualifications of the selected candidate.

Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.

Application Deadline

Job openings are posted for a minimum of seven calendar days. The review and selection process maybegin as early as the eighth day after posting.Thisopening may be removed from posting boards and filled anytime after the minimum posting period has ended.

U-M EEO Statement

The University of Michigan is an equal employment opportunity employer.

Job Opening ID

252278

Working Title