Research Fellow - Hematology - Mondello lab

Mayo Clinic; Rochester (MN); Vor Ort; USD 52.000 - 70.000; Vollzeit

Zusammenfassung

The Mondello lab at Mayo Clinic in Rochester seeks a post-doctoral research fellow with prior wet lab experience for 2-3 years in a relevant biomedical field (molecular biology, immunology, or genomics). The role focuses on epigenetic dysregulations in B cell malignancy and tumor microenvironment interactions, using genomic, epigenomic, and transcriptomic profiling and mouse models.

Responsibilities include bench work such as viral transfection, immunoprecipitation, flow cytometry, and western

Qualifikationen

• Prior wet lab experience in biomedical field; 2-3 year post-doc expected.
• The applicant should have experience with techniques listed or be open to training.
• On-site work is required at Mayo Clinic.

Aufgaben

• Execute bench work including viral transfection and immunoprecipitation.
• Perform flow cytometry and western blotting on primary cells and lines.
• Conduct mouse work: immunization, transplant, genotyping, and colony maintenance.

Kenntnisse

Wet lab experience

Molecular biology

Immunology

Genomics

Tools

Flow cytometry

Western blotting

Immunoprecipitation

Viral transfection

Mouse work

Jobbeschreibung

The Mondello lab is looking for a post-doctoral research fellow with prior wet lab experience for 2-3 years in relevant biomedical field (e.g., molecular biology, immunology and/or genomics).

The research focus of the Mondello lab is epigenetic dysregulations in B cell malignancy and their impact on the tumor microenvironment.By combining genomic, epigenomic and transcriptomic profiling approaches of patient samples and lymphoma cells lines together with genetically modified mouse models, the lab will identify and functionally characterize recurrent genetic lesions affecting chromatin modifiers and transcription factors, determine the role of these alterations in modulating the tumor-immune crosstalk and ultimately use this information to develop specific and potent therapeutic strategies.

The expectation is the applicant will execute bench work, including but not limited to viral transfection, immunoprecipitation, flow cytometry, western blotting of primary andlymphomacell line,as well as mouse work,includingbut not limited to immunization, transplant, genotyping and mouse colony maintenance.

Prior experience in some the above-mentioned techniquesis expected but additional training will be provided. The applicant will be required to work on site.