Research Associate / Senior Research Associate, Lead Discover

Treeline; Watertown (MA); On-site; USD 92,000 - 107,000; Full time

Job summary

Treeline Biosciences seeks a Research Associate to join our Watertown, MA team, supporting drug discovery projects and delivering high-quality data. You will perform crystallography and biophysical experiments, collaborating across biophysics, biology, computational chemistry, and medicinal chemistry.

The ideal candidate has a BS/MS in life sciences and 2+ years of experience, with a track record in lab operations, protein expression or binding assays, and familiarity with crystallography

Qualifications

• BS./M.S. degree in biology/biochemistry/chemistry with 2+ years life sciences experience.
• Operate sensitive lab equipment (liquid handlers, imagers, microscopes).
• General lab techniques: pipetting, buffer preparation, etc.
• Deliver detailed results within defined timelines and collaborate in a multidisciplinary team.
• Experience with protein expression or activity and binding assays.
• Preference for X-ray crystallography workflow and biophysical characterization (SPR, BLI, MST, ITC).
• Linux environment and/or Shell/Python scripting is a plus.
• Enthusiasm for science and teamwork.

Responsibilities

• Become a key contributor to Structural Biology and Biophysics teams, supporting insights for multiple drug programs.
• Work with Treeline Lab Operations staff and external vendors to ensure smooth operations.
• Collaborate with Lead Discovery team to characterize ligand binding and establish SAR.

Skills

Lab operations

Structural biology

Biophysics

Protein binding assays

X-ray crystallography

SAR analysis

Python scripting

Team collaboration

Education

BS./M.S. in biology/biochemistry/chemistry

Tools

Liquid handlers

Automated imagers

Microscopes

Linux

Shell/Python scripting

Job description

About Treeline

Treeline Biosciences is an innovative biotechnology company, founded by an experienced team of biopharmaceutical scientists and executives, committed to developing innovative medicines against difficult to drug targets in cancer and other life-threatening diseases. We employ an aggressive, integrated approach that applies modern and emerging tools in lead discovery, medicinal chemistry, antibody-drug conjugates, and computation to reduce the time and risks of drug discovery.

About The Role

We are seeking a highly motivated and experienced Research Associate to join our Watertown, MA team to support the drug discovery projects and exploration, delivering high-quality scientific data and insights to drive small molecule drug discovery. Specifically, this position will carry out and optimize crystallography and biophysical experiments alongside colleagues within both the multi-disciplinary Lead Discovery organization across biophysics, biochemistry, structural biology, and protein production, as well as the broader research and development organization including biology, computational chemistry, and medicinal chemistry. The ideal candidate will take a lead on lab equipment operation/maintenance, execute on structural experiments, and effectively communicate results to colleagues within Lead Discovery and project teams.

Responsibilities

• Become a key contributor to our internal Structural Biology and Biophysics teams, supporting our capability to provide both routine and novel insights to multiple drug programs.
• Work with Treeline Lab Operations staff and external vendors to ensure smooth laboratory operations.
• Collaborate with other members of the Lead Discovery team (protein sciences, biochemistry, mass spectrometry) to characterize small molecule ligand binding and establish SAR.

Qualifications

• BS./M.S. degree in a scientific or technical field related to biology, biochemistry, or chemistry and 2+ years work experience in life sciences sector.
• Ability to maintain and operate sensitive lab equipment, like liquid handlers, automated imagers, and microscopes.
• General laboratory experience and knowledge: pipetting, preparing buffer solutions, etc.
• Ability to work efficiently and deliver detailed results within defined timelines and to collaborate in a multidisciplinary team.
• Experience with protein expression or protein activity and binding assays.
• Preference for candidates with industry experience or academic training in some aspects of the X-ray crystallography workflow (setting screens, crystal optimization and harvesting) and biophysical characterization of protein or small molecule interactions (SPR, BLI, MST, ITC, etc).
• Working knowledge of a Linux computation environment and/or Shell/python scripting is a plus.
• Enthusiasm for science and working in a team environment that values good work and rapid progress.

This position is classified as exempt. The anticipated annual base salary range for candidates who will work in Watertown is $92,173 - $106,882. The final base salary offered to the successful candidate will be dependent upon several factors that may include but are not limited to the type and length of experience within the job, and other factors. Treeline Biosciences is a multi-state employer, and this salary range may not reflect positions that work in other cities or states.

Notice to Search Firms/Third-Party Recruitment Agencies (Recruiters)

The Human Resources team manages the recruitment and employment process for Treeline Biosciences. To protect the interests of all parties involved, Treeline Biosciences will only accept resumes from a recruiter if an executed search agreement directed to the particular position or positions is in place at the start of the recruitment effort. Unsolicited resumes sent to Treeline Biosciences from recruiters do not constitute any type of relationship between the recruiter and Treeline Biosciences and do not obligate Treeline Biosciences in any way to pay fees should we hire from those resumes. Recruiters are requested not to contact or present candidates directly to our hiring manager or employees.