Biomarker Program Lead, Clinical (Oncology)

Treelinebiosciences; Watertown (MA); On-site; USD 187,200 - 200,000; Full time

Job summary

Treeline Biosciences is seeking a Biomarker Lead to design and execute biomarker plans across clinical programs, coordinating assay transfer, validation, and data integration to ensure timely, high-quality results.

The role requires a PhD in Life Sciences and 4–5 years in clinical biomarkers or translational medicine, with CRO oversight and oncology/immunology experience preferred.

Qualifications

• PhD-level knowledge in biomarker science and assays.
• Experience with CROs and lab oversight.
• Oncology/immunology/neuroscience experience is a plus.

Responsibilities

• Develop and oversee biomarker plans for each clinical protocol.
• Identify and qualify bioassay labs/CROs for biomarker assays.
• Lead assay transfer from translational biology to labs/CROs with validation.
• Oversee testing at bioassay labs/CROs ensuring quality and compliance.
• Collaborate with Clinical Development, Operations, Translational Biology, Data Management, Biostatistics, and Regulatory.
• Provide updates on biomarkers to internal stakeholders.
• Analyze biomarker data with Translational Biology to test program hypotheses.

Skills

Biomarker planning

Assay transfer & validation

Cross-functional leadership

Communication

Project management

Education

PhD in Life Sciences / related field

Job description

Biomarker Lead

The Biomarker Lead will be accountable for biomarker planning and execution across one to two clinical programs, with a focus on programs approaching or in the clinic. This includes designing biomarker plans for each program, identifying appropriate bioassay labs/CROs, managing assay transfer and validation studies, and ensuring biomarker data are ingested, tracked, QCed, and integrated efficiently. The successful candidate will serve as the central point of accountability for biomarkers for their program, enabling high-quality and timely data delivery that supports Treeline’s mission to advance precision medicine.

Responsibilities

• Develop and oversee biomarker plans for each clinical protocol.
• Identify and qualify bioassay labs/CROs for biomarker assays
• Lead assay transfer from Translation biology teams to bioassay labs/CROs, ensuring validation and qualification.
• Oversee testing at bioassay labs/CROs, ensuring quality, compliance, and adherence to protocol requirements.
• Collaborate with Clinical Development, Clinical Operations, Translational Biology, Data Management, Biostatistics, and Regulatory to ensure biomarker deliverables align with clinical program needs.
• Provide updates on biomarkers to internal stakeholders.
• Work with Translational Biology and Clinical Development colleagues to analyze biomarker data and test key program hypotheses.

Qualifications

• PhD with postdoctoral training in Life Sciences, Cell Biology, Molecular Biology, Immunology, or a related field.
• 4–5 years of industry experience in a clinical setting, in clinical biomarkers, translational medicine, or a related function within biotech/pharma.
• Proven expertise in assay transfer, validation, and qualification with CRO and lab oversight experience.
• Knowledge of biomarker assay platforms (flow cytometry, IHC, NGS, proteomics, ligand binding assays) and their clinical application.
• Excellent organizational, cross-functional leadership, and communication skills, with the ability to manage multiple workstreams across one to two programs in a fast-paced environment.
• Oncology experience strongly preferred. Immunology and/or neuroscience experience considered upside.
• Experience with development of companion diagnostics (CDx) considered a plus.

This position is classified as exempt. The anticipated annual base salary range for candidates who will work in Watertown is $187,200 - $200,000. The final base salary offered to the successful candidate will be dependent upon several factors that may include but are not limited to the type and length of experience within the job, and other factors. Treeline Biosciences is a multi-state employer, and this salary range may not reflect positions that work in other cities or states.

Recruitment fraud statement

Please be aware of recruitment fraud and related job scams, where scammers present themselves as recruiters but are seeking to steal money or personal information. Keep the following in mind to protect yourself:

• Treeline Biosciences will never ask for money from you as part of our recruitment process. Do not provide bank details or pay somebody for the promise of a job at Treeline.
• We do not conduct interviews through RingCentral, Skype or Telegram.
• Our job openings are first posted to treeline.bio/careers. If you locate a listing for a Treeline job on another site, please ensure it is also posted on our careers website.
• You can find more information about job scams at consumer.ftc.gov/articles/job-scams.
• To report job scams, head to ReportFraud.ftc.gov.

Notice to Search Firms/Third-Party Recruitment Agencies (Recruiters)

The Human Resources team manages the recruitment and employment process for Treeline Biosciences. To protect the interests of all parties involved, Treeline Biosciences will only accept resumes from a recruiter if an executed search agreement directed to the particular position or positions is in place at the start of the recruitment effort. Unsolicited resumes sent to Treeline Biosciences from recruiters do not constitute any type of relationship between the recruiter and Treeline Biosciences and do not obligate Treeline Biosciences in any way to pay fees should we hire from those resumes. Recruiters are requested not to contact or present candidates directly to our hiring manager or employees.