Research Associate, In Vivo Biology

Cugene Inc.; Waltham (MA); Vor Ort; USD 60.000 - 90.000; Vollzeit

Benefits dieser Stelle

Medical insurance

Paid time-off

Sick leave

401 (K) Plan with Company Match

Holidays

Free on-site gym access

On-site cafeteria

Free parking

Zusammenfassung

CUGENE Inc. is seeking a highly motivated Research Associate to join our drug discovery team focused on cancer immunotherapies.

The role supports in vitro immunology assays and in vivo mouse model studies, working with PhD-level scientists to plan experiments, analyze results, and deliver high-quality data toward IND-enabling studies. The successful candidate will thrive in a fast-paced startup, contribute across study design, execution and data interpretation, and will have the title and level

Qualifikationen

• BS or MS in Biology, Immunology, Animal science, Pharmacology, or related life science with 1–3 years of academic or industrial working experience.
• Demonstrated hands-on experience with in vivo mouse studies, preferably tumor models in oncology or immune-oncology.
• Ability to independently perform routine mouse procedures.
• Experience with sterile techniques and mammalian cells culturing.
• Basic molecular and cell biology skills to conduct cell-based immunological assays.

Aufgaben

• Independently perform routine in vivo studies.
• Perform common dosing routes, including subcutaneous (SC), intraperitoneal (IP), intravenous (IV) administration and oral gavage; Tumor cell implantation and establishment by SC or IV;
• Support and execute mouse tumor studies including tumor measurement, body weight monitoring, treatment administration and study monitoring.
• Perform blood collection, including submandibular/facial vein sampling and terminal cardiac puncture, as appropriate.
• Conduct tumor and tissues collection, processing, and preparation for downstream analyses.
• Experienced in mouse xenograft and syngeneic tumor models are highly preferred. Additional oncology or immunology animal model development experience or surgical skills would be a plus.

Kenntnisse

Immunology

Mouse handling

Molecular biology

Data analysis

Ausbildung

BS or MS in Biology, Immunology, Animal science, Pharmacology, or related life science

Tools

Flow cytometry

ELISA

GraphPad Prism

Jobbeschreibung

CUGENE Inc. is dedicated to the discovery and development of innovative medicines for the treatment of cancer and autoimmune disease. We are driven by our mission to improve lives through harnessing the power of human immune system to fight disease. We strive to build a diverse and ethical environment that places innovation, integrity, and accountability at the heart of our cultures. We value our people with commitments and responsibility and are committed in seeking highly skilled and dedicated individuals in achieving our mission together, providing a Cure for Life.

ROLE DESCRIPTION

We are seeking a highly motivated Research Associate to join our drug discovery team focused on developing innovative cancer immunotherapies. The successful candidate will be integral member of a highly collaborative research team and will primarily support both in vitro immunology cell-based assays, and in vivo animal model studies. The candidate will work closely with PhD- level scientists to plan and design studies, conduct precise experiments, analyze and organize results, and deliver high-quality data to advance our immune-oncology programs toward IND-enabling studies and clinical development. This is an exciting opportunity for a passionate candidate who enjoys working in a fast-paced start up environment and wants to make a direct contribution to the development of novel cancer therapeutics. The final title and level will be determined based on education, experience, technical expertise and demonstrated research accomplishments.

BASIC QUALIFICATIONS

• BS or MS in Biology, Immunology, Animal science, Pharmacology, or a related life science discipline with at least 1-3 years of academic or industrial working experience.
• Demonstrated hands-on experience with in vivo mouse studies, preferably tumor models in oncology or immune-oncology.
• Ability to independently perform routine mouse procedures.
• Experience with sterile techniques and mammalian cells culturing.
• Basic molecular and cell biology skills to conduct cell-based immunological assays.

PREFERRED QUALIFICATIONS:

• Experience with syngeneic and/or xenograt mouse tumor models.
• Experience with ELISA, multicolor flow cytometry and other immunological/cell-based assays.
• Proficient in Graphpad, Flowjo or other data analysis and graphic software.
• Excellent skills in written and oral communication, organization and multitasking, and working in a highly collaborative and cross-functional research environment.

RESPONSIBILITIES

• Independently perform routine in vivo studies.
• Perform common dosing routes, including subcutaneous (SC), intraperitoneal (IP), intravenous (IV) administration and oral gavage; Tumor cell implantation and establishment by SC or IV;
• Support and execute mouse tumor studies including tumor measurement, body weight monitoring, treatment administration and study monitoring.
• Perform blood collection, including submandibular/facial vein sampling and terminal cardiac puncture, as appropriate.
• Conduct tumor and tissues collection, processing, and preparation for downstream analyses.
• Experienced in mouse xenograft and syngeneic tumor models are highly preferred. Additional oncology or immunology animal model development experience or surgical skills would be a plus.

In Vitro:

• Maintaining and culturing mammalian cell lines and primary cells using appropriate sterile techniques.
• Perform in vitro human/mouse cell-based assays, multi-color flow cytometry, ELISA, and other immunological assays.
• Generate high-quality experimental data, perform data analysis with guidance from scientists.
• Maintain accurate and timely records in an electronic laboratory notebook (ELN).

COMPANY BENEFITS

• Medical insurance
• Paid time-off
• Sick leave
• 401 (K) Plan with Company Match
• Holidays
• Free on-site gym access
• On-site cafeteria
• Free parking

EQUAL EMPLOYMENT OPPORTUNITY

At CUGENE, our workplace reflects the value of diversity and inclusion, and we recognize each employee as an integral part of our success. CUGENE Inc is an equal opportunity employer and is committed to equal opportunity to all employees and job applications without regard to race, color, religion, national origin, gender, sexual orientation, marital status, medical condition, disability, or veteran status.

A qualified candidate will be hired at the appropriate level commensurate with education and experience.