Research Associate II - T Cell Therapeutics Research Laboratory

City of Hope; Duarte (CA); On-site; USD 70,000 - 90,000; Full time

Job summary

City of Hope Beckman Research Institute seeks a Research Associate II to support CAR T-cell therapies in next-gen cancer models. You will culture T cells, develop organoid and tumor-on-a-chip platforms, and perform functional assays with ELISAs.

The role includes flow cytometry, data analysis, murine tissue work, and ensuring GLP-compliant lab practices. A Bachelor's degree with related experience is required; a Master’s is preferred.

Qualifications

• 2+ years of related experience with a Bachelor's degree or 1+ year related experience with a Master’s degree.
• Meticulous attention to detail and accuracy in lab work and recordkeeping.
• Hands-on experience with cellular immunology and GLP practices.

Responsibilities

• Perform tissue culture using aseptic techniques and maintain cell lines.
• Support development of organoid models and tumor-on-a-chip platforms.
• Conduct T cell functional assays including cytotoxicity and cytokine production.
• Perform multicolor flow cytometry staining and data analysis.
• Assist with murine surgical procedures and tissue harvesting.
• Maintain and update laboratory protocols and GLP-compliant documentation.

Skills

T cell culture

Flow cytometry

ELISA assays

Cellular immunology

Education

Bachelor's degree

Master's degree preferred

Tools

GLP compliance

Cryopreservation

Job description

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

A Research Associate II position is available in the lab of Dr. Christine Brown of the T Cell Therapeutics Research Laboratories (TCTRL). This is a fast-paced lab involved in cutting-edge technology, research and clinical immunotherapeutic programs. You will support the evaluation of CAR T-cell therapies in next-generation cancer models, including patient-derived organoid cultures and organ-on-a-chip platforms, as well as the development and evaluation of novel blood- and iPSC-derived immune effector cell therapies. We will train new personnel in project specific techniques and procedures. Please note, work hours may vary.

For an overview of research interests, please visit here

As a successful candidate you will:

• Perform tissue culture using aseptic techniques, including media preparation, passaging, maintenance, and cryopreservation of T cell lines and pluripotent stem cells.
• Support the development of next-generation solid cancer models, including patient-derived organoids and tumor-on-a-chip platforms.
• Conduct T cell functional assays, including cytotoxicity and cytokine production assays, as well as ELISAs.
• Perform cell staining for multicolor flow cytometry and analyze flow cytometry data.
• Assist with murine surgical procedures, tissue harvesting, and sample preparation.
• Revise and maintain laboratory protocols and procedures.
• Provide routine laboratory support and maintenance in accordance with Good Laboratory Practice (GLP) principles.

Your qualifications should include:

• Bachelor’s degree. Masters degree preferred
• 2+ years of related experience with a Bachelor’s degree or 1+ year related experience with a Master’s degree.
• Meticulous attention to detail and accuracy in lab work as well as accurate recordkeeping and lab documentation are a must.
• Hands-on experience with cellular immunology and standard good laboratory practices (GLP) desired

City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.

City of Hope is an equal opportunity employer.