Research Associate II, Production

BigHat; San Mateo, Northern (CA, KY); Hybrid; USD 88,000 - 100,000; Full time

Benefits offered by this job

Bonus

Stock options

Benefits

Job summary

BigHat Biosciences seeks a Research Associate II, Production to power our high-throughput, automated platform for antibody production and deep molecular characterization in San Mateo, CA.

You will perform automated/liquid handling tasks, help scale the platform, and contribute to SOPs and data generation while collaborating with a multidisciplinary team to optimize workflows.

Qualifications

• BS in Biology or Chemistry; 2+ years industry experience.
• Experience in process execution, laboratory method development, optimization, and troubleshooting.
• Ability to work specific workday schedules, e.g., 7AM–3PM or 10AM–6PM.
• Hands-on experience with automated liquid handlers; familiarity with LIMS preferred.
• Experience with molecular biology techniques and general lab practices.
• Strong time management and ability to manage multiple projects in a start-up environment.
• Excellent record-keeping and communication with multidisciplinary teams.

Responsibilities

• Perform automated and manual high-throughput processing on the BigHat platform, including DNA preparation, protein expression, and protein characterization.
• Contribute to the scaling up of BigHat’s platform and production-grade data generation.
• Support PRAS by contributing to in-house reagent manufacturing efforts.
• Execute experiments to optimize platform performance and efficiency.
• Maintain detailed experimental records using BigHat’s documentation tools and communicate results clearly.
• Collaborate on creating SOPs for sample processing.
• Work with the team to identify and implement improvements to production workflows and lab systems.
• Operate automated liquid handlers and analytical instruments to ensure efficient lab operations.

Skills

Automated liquid handlers

DNA preparation

Protein expression/characterization

LIMS experience

Cross-functional collaboration

Documentation

Education

Bachelor's degree in Biology or Chemistry

Tools

Hamilton

OpenTrons

Tecan

Agilent systems

LIMS

Job description

Research Associate II, Production

Department: Lab Science

Employment Type: Full Time

Location: San Mateo, CA

Description

The role: BigHat Biosciences is seeking a self-motivated individual for a Research Associate II, Production role to power our high-throughput, automated platform for antibody production and deep molecular characterization.

Key Responsibilities

• Perform automated and manual high-throughput processing on the BigHat platform, including DNA preparation, protein expression, and protein characterization.


• Contribute to the scaling up of BigHat’s platform and production-grade data generation.


• Support BigHat’s Platform Reagents & Assay Support (PRAS) function by contributing to in-house reagent manufacturing efforts.


• Execute experiments to optimize the performance efficiency of BigHat’s platform.


• Keep a detailed record of all experiments using BigHat’s documentation tools, and clearly communicate results and challenges.


• Collaborate on the creation of laboratory standard operating procedures (SOPs) for sample processing.


• Collaborate closely with BigHat team members to identify, design, and implement critical process and operational improvements to production workflows and laboratory systems.


• Operate automated liquid handlers and analytical instruments to ensure all lab and platform operations run efficiently.

Skills Knowledge and Expertise

• BS in Biology or Chemistry, with 2+ year(s) of industry experience


• Experience in process execution, laboratory method development, optimization, and troubleshooting.


• Ability and willingness to work specific workday schedules as needed, for example 7AM to 3PM or 10AM to 6PM.


• Hands-on experience with, or interest in, automated liquid handlers (e.g. Hamilton, OpenTrons, Tecan, Agilent systems). Experience with LIMS is a nice-to-have.


• Experience with molecular biology techniques and general lab practices.


• Efficient time management and ability to work on several projects simultaneously, in a dynamic start-up environment.


• Strong interpersonal skills and ability to effectively communicate with members of a multidisciplinary team.


• Excellent record keeping abilities to document experimental work and analytical data.


• Nice-to-haves include previous experience working with barcoding systems, inventory tracking, and experience with Google Workspace tools (Docs, Sheets, Slides, etc.)

Total Rewards

The salary estimated for this position is $88,000 - $100,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.