Research Assistant II: Cardioverse Heart Tissue & Data Lab

JAX; Farmington (CT); In loco; USD 43.000 - 72.000; Tempo pieno

Descrizione del lavoro

The Jackson Laboratory for Genomic Medicine in Farmington, CT seeks a Research Assistant III to join the ARPA-H Cardioverse program. You will culture iPSC lines, generate iPSC-derived cardiomyocytes, and fabricate 3D engineered heart tissues.

Work includes functional assays, data management, and collaboration with computational teams building digital twin models. A Bachelor’s degree with relevant lab experience or a Master’s with fewer years are required; strong organization and independence are

Competenze

• Bachelor’s degree in biology, biomedical science, bioengineering, or related field with 3+ years of relevant laboratory experience, or a Master’s degree with 1+ year.
• Hands-on experience with mammalian cell culture; iPSC culture and differentiation strongly preferred.
• Experience with cardiomyocytes, tissue engineering, or physiological assays such as contractility or calcium imaging is a plus.
• Comfort with high-throughput, multiwell workflows and meticulous record keeping.
• Experience with pharmacology or compound screening is a plus.
• Basic data analysis skills (Excel, Prism; R or Python a plus).

Mansioni

• Culture, differentiate, and quality-control iPSC lines from genetically diverse donors, and generate iPSC-derived cardiomyocytes (iPSC-CMs) at scale.
• Fabricate 3D EHTs and microtissues in multiwell formats, following standardized protocols to ensure reproducibility across lines, batches, and operators.
• Perform functional assays on EHTs, including contractile force, kinetics, and calcium handling, and test compounds in dose-response studies for drug safety and efficacy.
• Prepare samples for multi-omic profiling (RNA-seq and single-cell assays) and imaging.
• Document experiments in detail, including metadata, line identifiers, and batch information, and follow data management practices that support computational modeling.
• Process and organize data, apply quality-control criteria, and work closely with computational collaborators who build the digital twin models.

Conoscenze

Mammalian cell culture

iPSC culture

Cardiomyocytes

Tissue engineering

High-throughput workflows

Record keeping

Data analysis

Communication

Formazione

Bachelor’s degree in biology/biomed/biotech

Master’s degree with 1+ years experience

Strumenti

Excel

Prism

R

Python

Descrizione del lavoro

The Jackson Laboratory for Genomic Medicine in Farmington, CT seeks a Research Assistant III to join the ARPA-H Cardioverse program. You will culture iPSC lines, generate iPSC-derived cardiomyocytes, and fabricate 3D engineered heart tissues.

Work includes functional assays, data management, and collaboration with computational teams building digital twin models. A Bachelor’s degree with relevant lab experience or a Master’s with fewer years are required; strong organization and independence are