Cardiac Physiology & Genomics Postdoc: 3D Heart Models

The Jackson Laboratory; Farmington (CT); On-site; USD 66,000 - 76,000; Full time

Job summary

The Hinson lab at The Jackson Laboratory for Genomic Medicine and UConn Health seeks an independent, PhD-level scientist to study inherited heart failure and muscle disorders using human iPSC-derived engineered heart tissues and mouse models. Projects include 3D EHT physiology, murine cardiac phenotyping, Perturb-seq-style genetic screening, and sarcomere assembly research.

The role involves collaboration with an international network, strong quantitative analysis, and a track record of

Qualifications

• PhD (or equivalent) in cell biology, molecular biology, physiology, genetics, bioengineering, or a related field.
• Strong background in at least one: stem cell differentiation, cardiac or muscle physiology, mouse models of disease, genome editing (CRISPR), or single-cell genomics.
• Experience with advanced imaging, protein-protein interaction studies, or computational analysis of sequencing data is a plus.
• A record of scientific productivity, including publications, and strong written and verbal communication skills.
• Ability to work independently and collaboratively in a multidisciplinary team.

Responsibilities

• Work on cardiac physiology in 3D engineered heart tissue (EHT) models using human iPSC-derived tissues.
• Characterize mouse models of heart failure in vivo including echocardiography and histology.
• Apply pooled, Perturb-seq-style approaches in the heart to define gene function and disease mechanisms at scale.
• Collaborate on sarcomere assembly research with international teams using stem cell biology, 3D microtissue assays and advanced imaging.

Skills

Stem cell differentiation

Cardiac physiology

Muscle physiology

Mouse models of disease

Genome editing (CRISPR)

Single-cell genomics

Imaging

Publications

Scientific communication

Education

PhD in a relevant field

Tools

CRISPR

Single-cell sequencing

Job description

The Hinson lab at The Jackson Laboratory for Genomic Medicine and UConn Health seeks an independent, PhD-level scientist to study inherited heart failure and muscle disorders using human iPSC-derived engineered heart tissues and mouse models. Projects include 3D EHT physiology, murine cardiac phenotyping, Perturb-seq-style genetic screening, and sarcomere assembly research.

The role involves collaboration with an international network, strong quantitative analysis, and a track record of