Remote Senior Scientist, Translational Bioanalysis

Spyre Therapeutics, Inc.; United States; Remote; USD 160,000 - 202,000; Full time

Benefits offered by this job

Performance bonus

Equity grant

Unlimited PTO

Company-wide shutdowns

Remote work

Job summary

Spyre Therapeutics, Inc. is seeking a Senior Scientist, Translational Science to drive outsourced bioanalytical and biomarker activities for clinical programs.

You will lead PK, immunogenicity, and PD assays, collaborate with CROs, and ensure adherence to regulatory requirements and program timelines. The role requires advanced degree with relevant industry experience, proficiency in multiple platforms (LC-MS/MS, ELISA, electrochemiluminescence, MSD, multiplex assays), and strong communication

Qualifications

• PhD in biology, biochemistry, pharmacology, chemistry or related field with 2+ years industry experience.
• MS with 5+ years in regulated bioanalysis and drug development.
• Experience with PK and immunogenicity assays for large molecules.
• Experience overseeing CROs and reviewing technical documents and data.

Responsibilities

• Manage outsourced bioanalytical activities for PK, immunogenicity, and biomarker assays at CROs.
• Design, qualification, validation, and maintenance of bioanalytical methods per regulations.
• Review protocols, plans, reports, and data packages for quality and integrity.
• Coordinate with CROs and internal partners on milestones, quotes, and purchase orders.
• Plan clinical sample analysis across studies, prioritizing testing and timelines.
• Collaborate with SMEs to resolve issues in assay development and analysis.
• Evaluate data, summarize conclusions, and communicate results to translation science team.
• Contribute biosanalytical content to lab manuals and data transfer agreements.
• Other duties as assigned.

Skills

PK assays

Immunogenicity assays

Bioanalytical platforms

CRO oversight

Regulatory compliance

Education

PhD in biology/biochemistry/pharmacology/chemistry or related field

MS with 5+ years in regulated bioanalysis

Tools

LC-MS/MS

ELISA

Electrochemiluminescence

MSD

Multiplex assays

Job description

Spyre Therapeutics, Inc. is seeking a Senior Scientist, Translational Science to drive outsourced bioanalytical and biomarker activities for clinical programs.

You will lead PK, immunogenicity, and PD assays, collaborate with CROs, and ensure adherence to regulatory requirements and program timelines. The role requires advanced degree with relevant industry experience, proficiency in multiple platforms (LC-MS/MS, ELISA, electrochemiluminescence, MSD, multiplex assays), and strong communication