Remote Senior Principal Statistical Programmer Leader

WCG Clinical, Inc.; Honolulu (HI); Remote; USD 131,000 - 160,000; Full time

Benefits offered by this job

Health insurance

401(k) with company match

Tuition reimbursement

Paid holidays

Job summary

WCG Clinical, Inc. is seeking a Senior Principal Statistical Programmer to act as a senior technical leader in statistical programming for clinical trials and DMC deliverables.

This role requires deep expertise in SAS programming and R, with a strong track record in CDISC standards and regulatory submissions. You will design and develop complex outputs, mentor staff, and drive automation and best practices across studies, partnering with biostatistics, data management, and IT to ensure

Qualifications

• Master’s degree required; in limited circumstances, an equivalent combination of education and directly relevant professional experience may be considered.
• Deep expertise in SAS programming, including complex analyses and regulatory deliverables.
• Proficiency in R programming is a must.
• Demonstrated experience with CDISC standards and regulatory requirements.
• Proven ability to independently lead complex programming efforts across studies.
• Experience mentoring staff and driving technical standards or best practices.

Responsibilities

• Serve as a senior technical expert in statistical programming, providing guidance across multiple studies or functional areas.
• Design, develop, validate, and oversee complex statistical programming deliverables, including analysis datasets, tables, listings, and figures.
• Lead the development, validation, and continuous improvement of DMC macros and programming standards.
• Provide technical oversight and review of programming work to ensure quality, compliance, and consistency across deliverables.
• Drive the establishment and adoption of programming standards, best practices, and process improvements.
• Collaborate with biostatistics and study teams to support complex trial designs, analyses, and DMC reporting.
• Independently manage and prioritize programming activities across multiple studies or initiatives.
• Mentor and provide technical leadership to statistical programming staff, supporting skill development and best practices.
• Contribute technical expertise to proposals, project planning, and scope discussions as needed.
• Provide technical oversight for programming activities supporting regulatory submissions and inspection readiness.
• Ensure programming deliverables align with regulatory expectations, submission requirements, and CDISC standards.
• Influence programming approaches, standards, and best practices across multiple studies or programs.
• Serve as a technical escalation point for complex programming, data, or deliverable issues, leading resolution of highly complex or ambiguous challenges.
• Provide expert interpretation of SAPs, protocols, and study documents, translating requirements into programming strategy.
• Champion process improvements, automation, and innovative approaches to enhance efficiency, scalability, and consistency of programming deliverables.

Skills

SAS programming

R programming

CDISC standards

Regulatory deliverables

Mentoring staff

Leadership across studies

SAS environments

Education

Master’s degree

Tools

SAS environments

Job description

WCG Clinical, Inc. is seeking a Senior Principal Statistical Programmer to act as a senior technical leader in statistical programming for clinical trials and DMC deliverables.

This role requires deep expertise in SAS programming and R, with a strong track record in CDISC standards and regulatory submissions. You will design and develop complex outputs, mentor staff, and drive automation and best practices across studies, partnering with biostatistics, data management, and IT to ensure