Remote Senior Principal Statistical Programmer – Lead & Innovate

WCG Clinical, Inc.; Little Rock (AR); Remote; USD 131,000 - 160,000; Full time

Benefits offered by this job

Health insurance

401(k) match

Tuition reimbursement

Paid holidays

Job summary

WCG is seeking a Senior Principal Statistical Programmer to serve as a senior technical leader, driving design, development, and standardization of high-quality statistical outputs for clinical trials. The role includes leadership across projects, mentoring staff, and shaping programming standards and best practices.

The position requires deep SAS expertise, proficiency in R, and CDISC knowledge, with coordination across biostatistics, data management, and study teams to ensure compliant,

Qualifications

• Master’s degree required.
• Minimum 8–10 years of statistical programming experience in a clinical trial environment.
• Deep expertise in SAS programming, including complex analyses and regulatory deliverables.
• Proficiency in R programming.
• Demonstrated experience with CDISC standards and regulatory requirements.
• Proven ability to independently lead complex programming efforts across studies.
• Experience mentoring staff and driving technical standards or best practices.
• Demonstrated ability to coordinate biostatistical projects, including planning and oversight of programming activities.

Responsibilities

• Serve as a senior technical expert in statistical programming, providing guidance across multiple studies or functional areas.
• Design, develop, validate, and oversee complex statistical programming deliverables, including analysis datasets, tables, listings, and figures.
• Lead the development, validation, and continual improvement of DMC macros and programming standards.
• Provide technical oversight and review of programming work to ensure quality, compliance, and consistency across deliverables.
• Drive the establishment and adoption of programming standards, best practices, and process improvements.
• Collaborate with biostatistics and study teams to support complex trial designs, analyses, and DMC reporting.
• Independently manage and prioritize programming activities across multiple studies or initiatives.
• Mentor and provide technical leadership to statistical programming staff, supporting skill development and best practices.
• Contribute technical expertise to proposals, project planning, and scope discussions as needed.
• Partner with IT and technology teams to support SAS environments, tools, and system validation efforts.
• Provide technical oversight for programming activities supporting regulatory submissions and inspection readiness.
• Ensure programming deliverables align with regulatory expectations, submission requirements, and CDISC standards.
• Influence programming approaches, standards, and best practices across multiple studies or programs.
• Serve as a technical escalation point for complex programming, data, or deliverable issues, leading resolution of highly complex or ambiguous challenges.
• Provide expert interpretation of SAPs, protocols, and study documents, translating requirements into programming strategy.
• Champion process improvements, automation, and innovative approaches to enhance efficiency, scalability, and consistency of programming deliverables.
• Other duties as assigned by supervisor.

Skills

SAS programming

R programming

CDISC standards

Technical leadership

Project coordination

Mentoring

Regulatory deliverables

Education

Master’s degree in a related field

Tools

SAS environments

Job description

WCG is seeking a Senior Principal Statistical Programmer to serve as a senior technical leader, driving design, development, and standardization of high-quality statistical outputs for clinical trials. The role includes leadership across projects, mentoring staff, and shaping programming standards and best practices.

The position requires deep SAS expertise, proficiency in R, and CDISC knowledge, with coordination across biostatistics, data management, and study teams to ensure compliant,