Remote AI Peptide Discovery Scientist

latch.bio; San Francisco (CA); Remote; USD 140,000 - 180,000; Full time

Job summary

Latch.bio seeks an AI Biologist to lead peptide-discovery benchmarks and guide AI agents through complex biological reasoning. You will set the standard for ground truth and shape tasks and datasets spanning target tractability to lead nomination.

You will work with software engineers to implement judgment into new workflows, emphasizing rigorous experimental design, uncertainty handling, and robust data analysis in Python or R.

Qualifications

• PhD in peptide chemistry, biochemistry, biophysics, structural biology, medicinal chemistry, or a related field.
• Senior, hands-on peptide discovery experience.
• Direct experience with display/selection, binding kinetics, binding-site mapping, or peptide developability.
• Deep expertise in at least one area and working fluency across the others.
• Strong command of experimental design and quantitative data analysis in Python or R; statistics.
• AI-ready from day one: daily use of Claude, Cursor, or similar agents.
• Bonus: peptide format/chemistry (macrocyclization, stapling, N-methylation, non-canonical residues, HELM).
• Bonus: target tractability or de novo design experience (PPI hotspots, Rosetta, RFdiffusion).

Responsibilities

• Define expert reasoning for peptide discovery questions and write gold-standard answers with rationale.
• Design realistic discovery scenarios across the arc from target tractability to lead nomination.
• Curate datasets from real programs and build Python pipelines for ground truth.
• Build workflows with software engineers to translate judgment into new tasks.
• Test agents’ ability to distinguish true signal from artifacts and reconcile conflicting evidence.
• Interrogate agent reasoning step by step and identify where improvements are needed.

Skills

AI-ready

Python or R

Peptide discovery

Experimental design

Quantitative data analysis

Statistics

Uncertainty handling

Education

PhD in peptide chemistry or related field

Tools

SPR/BLI

NMR

HDX-MS

Job description

Latch.bio seeks an AI Biologist to lead peptide-discovery benchmarks and guide AI agents through complex biological reasoning. You will set the standard for ground truth and shape tasks and datasets spanning target tractability to lead nomination.

You will work with software engineers to implement judgment into new workflows, emphasizing rigorous experimental design, uncertainty handling, and robust data analysis in Python or R.