Real World Evidence Manager

Vertex Pharmaceuticals Inc (US); Boston (MA); Hybrid; USD 132,000 - 198,000; Full time

Job summary

Vertex Pharmaceuticals Inc (US) seeks a Real World Evidence Manager to join the RWE team. The role applies epidemiology and real world data to assess disease natural history and support global observational research for portfolio products.

You will provide methodological and analytical support across Clinical Development, Global Medical Affairs, and other functions, while collaborating with vendors and influencing regulatory and clinical decisions.

Qualifications

• PhD preferred or MS/MPH in epidemiology, biostatistics, health economics and outcomes research, or similar required.
• Formal graduate training in Epidemiology/Health Services Research required.
• Minimum 2 years of experience in observational research within life sciences, academia, government or consulting.
• Ability to translate observational results to non-technical cross-functional audiences.

Responsibilities

• Support focused epidemiologic research for Vertex's pipeline and established portfolios, including natural history and literature reviews.
• Ensure scientific rigor for real world data analyses.
• Assess feasibility of data sources for disease areas and research questions.
• Design and defend fit-for-purpose observational research and select appropriate analytic methods.
• Collaborate with vendors to ensure project timelines and goals.
• Support Study Execution Teams for observational studies.
• Contribute to development of performance metrics and dashboards for RWE projects.
• Communicate findings clearly to internal audiences.
• Contribute to publications strategy through conference abstracts, presentations, and manuscripts.

Skills

Epidemiology

RWE methods

Study management

Regulatory awareness

Education

PhD in epidemiology/biostatistics

MS/MPH in related field

Tools

SAS

R

Job description

Job Description General Summary:

The Real World Evidence Manager is an integral member of the RWE team who leverages expertise in epidemiology, real world data, and other relevant disciplines to assess the natural history and real world outcomes for Vertex’s pipeline and portfolio products. The position will support cross-functional global observational research by providing methodological and analytical support for internal stakeholders, including Clinical Development, Global Medical Affairs, Global Patient Safety, and Government Affairs and Public Policy. The Manager will also execute on tactics related to the collection and/or analysis of real world data to inform relevant stakeholders such as regulatory affairs and clinical development.

Key Duties and Responsibilities:

• Support focused/targeted epidemiologic research in support of Vertex’s pipeline and established portfolios, including Natural History (NH) of disease and systematic literature reviews


• Ensure scientific rigor for real world data analyses


• Conduct feasibility assessment of relevant data sources for disease areas and research questions


• Provide insights and experience to design and defend fit-for-purpose epidemiologic observational research; Identify appropriate analytic methods aligned to research needs


• Collaborate with and manage vendors, to ensure meeting project timelines and goals


• Support Study Execution Teams for observational studies


• Contribute to development of performance metrics and dashboards for RWE projects


• Able to balance multiple projects in a fast-paced environment


• Utilize strong oral and visual communication skills and understanding of Vertex strategies to promote and translate value of RWD/RWE methods and studies across the company


• Excellent communication skills (oral and written) with internal and external audiences


• Contribute to company publications strategy via development of conference abstracts, presentations, peer- reviewed manuscripts based on the findings of RWE studies

Knowledge and Skills:

• Working knowledge of relevant RWE regulatory agency guidance and position papers and the opportunities to use RWE to inform regulatory decision making


• Demonstrated ability to design and execute observational research


• Strong interpersonal communication and study management skills


• Ability to take detailed observational study results and communicate them in a clear, non-technical manner to internal cross-functional teams, using language that resonates with the teams, while maintaining the integrity of key findings


• Ability to work collaboratively in a constantly changing, diverse, and matrix environment

Education and Experience:

• PhD (preferred) or MS/MPH in epidemiology, biostatistics, health economics and outcomes research, or similar required


• Formal graduate training in Epidemiology/Health Services Research required


• Minimum 2 years of experience working in observational research within the life sciences industry or relevant academic, government, or consulting environment

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range:

Pay Range: $132,100 - $198,100 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market‑leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

Company Information:

Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [e-mail].

Help Us Achieve Our Mission

Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1. Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 16 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X. We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.