Analytics CoE Senior Manager

Vertex Pharmaceuticals Inc (US); United States; Hybrid; USD 144,000 - 216,000; Full time

Job summary

Vertex Pharmaceuticals Inc (US) seeks a Senior Manager/Director to lead HEOR Analytics, focusing on real-world observational research and analyses using in-licensed data assets. The role supports disease/asset teams with study design, protocols, and executable analyses.

You will collaborate with statisticians to deliver insights, develop tools, and guide research objectives across therapeutic areas. Remote-eligible with flexible in-person/onsite arrangements.

Qualifications

• Advanced degree in health economics or a related discipline (e.g., mathematics, statistics, economics, epidemiology).
• Typically requires 6 years of relevant experience in health economics and outcomes research, or the equivalent combination of education and experience.

Responsibilities

• Leverage Vertex’s in-licensed RWE data assets to conduct queries and analyses supporting the product portfolio.
• Conduct feasibility assessments to inform design and execution of research projects.
• Perform health economic and outcomes research to characterize disease burden and healthcare resource utilization.
• Generate actionable insights to address key business questions from internal and external stakeholders.
• Lead development of study protocols, statistical analysis plans, and table shells.
• Support statistical programmers through data queries and analyses.
• Generate analytic reports, tables, and visualizations for internal stakeholders.
• Collaborate with cross-functional teams to improve efficiency of analytics operating model.
• Contribute to development and maintenance of internal analytic tools (libraries, macros, templates).
• Support HEOR disease/asset leads in identifying research gaps and objectives.

Skills

Advanced SAS programming

Excel proficiency

Observational research methods

Real-world data analysis (claims/EHR)

Project management

Statistical analysis

Communication skills

Team collaboration

Analytic reporting and visualization

Education

Advanced degree in health economics or related discipline

Tools

MarketScan

PharMetrics Plus

eLAAD+

Premier data

Job description

Job Description Vertex is seeking a talented and motivated individual with the desire to be part of a highly innovative company aimed at transforming the lives of people with serious diseases, their families and society. The Senior Manager Director role is within HEOR’s Analytics Center of Excellence (CoE), a specialized team that provides strategic and technical support to HEOR, Market Access & Pricing, and the broader commercial organization. In this role, the Senior Manager will primarily support HEOR disease/asset teams in real-world observational and claims data research activities. The Senior Manager will support colleagues looking to answer key questions that can be addressed using Vertex’s in-licensed RWE data assets. This includes planning and conducting analyses to inform on questions related to disease prevalence, disease burden and progression, healthcare resource utilization and costs, and treatment patterns in ‘real world’ patient populations. The Senior Manager is also expected to provide methodological expertise to research design, including development of study protocols, analysis plans, and table shells. This role will work closely with a team of statistical programmers to lead the execution of data queries and analyses. The role has flexibility to be in-person, hybrid, or remote.

Key Responsibilities

• Leverage Vertex’s in-licensed RWE data assets to conduct queries and analyses to support the Vertex product portfolio and development programs across a range of therapeutic and disease areas.
• Conduct feasibility assessments to inform design and execution of research projects.
• Conduct health economic and outcomes research to better characterize disease burden, healthcare resource utilization, co-morbidities, and treatment patterns in ‘real world’ populations.
• Generate actionable insights to address key business questions from internal and external stakeholders.
• Lead the development of study protocols, statistical analysis plans, and table shells.
• Support statistical programmers through the execution of data queries and analyses.
• Generate analytic reports, tables, and visualizations to communicate research findings effectively to internal stakeholders.
• Collaborate with cross-functional colleagues to improve efficiency of current analytics operating model.
• Contribute to the development, enhancement, and maintenance of internal analytic tools (e.g., programming libraries, reusable macros, table templates), to support the quality and consistency of data and analyses.
• Support HEOR disease/asset leads in assessment of research gaps and evidence generation objectives that may be addressed through observational research.

Qualifications

• Advanced degree in health economics or a related discipline (such as mathematics, statistics, economics, epidemiology).
• Typically requires 6 years of relevant experience in health economics and outcomes research, or the equivalent combination of education and experience (e.g., Doctorate degree and 2 years of experience, Master’s degree and 4 years of experience).
• Knowledge of observational research methods and their application to studies assessing disease burden, healthcare resource utilization, treatment patterns, comorbidities, and health outcomes studies in real-world patient populations.
• Hands‑on experience analyzing large patient‑level healthcare datasets, including open and closed claims, EHR/EMR data, and hospital chargemaster data (e.g., MarketScan, PharMetrics Plus, eLAAD+, Premier).
• Working knowledge of national healthcare coding systems, including diagnostic, procedure, and drug coding, as well as relevant healthcare system structures.
• Advanced proficiency in SAS programming and Excel required.
• Excellent written and oral communication skills, including the ability to clearly convey complex analytic findings to both technical and non‑technical audiences.
• Ability to plan, organize, and manage multiple projects simultaneously in different therapeutic areas.
• At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends.
• We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision‑making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range

Pay Range: $144,000 - $216,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job‑related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market‑leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week‑long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation

Flex Designation: Remote-Eligible Flex Eligibility Status: In this Remote-Eligible role, you can choose to be designated as:

• Remote: work remotely five days per week and come into the office on occasion – you’re always welcome on‑site; or select 2. Hybrid: work remotely up to two days per week; or select 3. On‑Site: work five days per week on‑site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Remote

Company Information

Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non‑discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E‑Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [e-mail]

Help Us Achieve Our Mission

Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion‑dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1‑mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH‑dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1. Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 16 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.