QC Scientist I — RNAi Analytics, 2nd Shift

Doist; Verona (WI); On-site; USD 90,000 - 108,000; Full time

Job summary

Arrowhead Pharmaceuticals, Inc. in Verona, Wisconsin, is seeking a Scientist I, Quality Control to support analytical method validation, transfer, and QC testing across our RNAi pipeline.

This role works in a fast-paced GMP lab, collaborating with Analytical Development and Manufacturing. You will analyze data from LC-MS, HPLC/UHPLC, GC, and endotoxin testing, maintain documentation per cGMP, and mentor colleagues.

Qualifications

• Bachelor's degree in Chemistry or a related field with 5+ years of lab experience.
• Master's degree with 3+ years of lab experience.
• Deep knowledge of cGMP and ICH requirements.
• Experience testing oligonucleotides, peptides, or synthetic biomolecules.
• Hands-on with LCMS, HPLC/UHPLC, Karl Fischer, and endotoxin testing.

Responsibilities

• Perform analytical testing of materials and products per validated methods.
• Execute method validation, transfer, and routine QC testing per cGMP/ICH.
• Operate and troubleshoot LC-MS, HPLC/UHPLC, GC, and related equipment.
• Analyze data including stability trends and degradation profiles.
• Investigate results and ensure data quality and compliance.
• Collaborate with Analytical Development, Manufacturing, and Quality teams.
• Lead discussions, troubleshoot analytical challenges, and drive improvements.
• Train colleagues on techniques and documentation practices.
• Maintain compliant documentation per GDP and SOPs.
• Support investigations and method improvements.

Skills

LC-MS operation

AEX-HPLC

RP-HPLC/UHPLC

Karl Fischer titration

LAL/endotoxin testing

Data interpretation

Education

Bachelor's degree in Chemistry or related field

Master's degree in Chemistry or related field

Tools

LC-MS

AEX-HPLC

RP-HPLC/UHPLC

Gas Chromatography (GC)

Karl Fischer titration

LAL endotoxin testing

Job description

Arrowhead Pharmaceuticals, Inc. in Verona, Wisconsin, is seeking a Scientist I, Quality Control to support analytical method validation, transfer, and QC testing across our RNAi pipeline.

This role works in a fast-paced GMP lab, collaborating with Analytical Development and Manufacturing. You will analyze data from LC-MS, HPLC/UHPLC, GC, and endotoxin testing, maintain documentation per cGMP, and mentor colleagues.