Protein Engineering Scientist I — High-Throughput Enzymes

New England Biolabs; Ipswich (MA); On-site; USD 80,000 - 90,000; Full time

Benefits offered by this job

Profit-sharing bonus

ESOP

10% 401k match

Benefits package

Job summary

New England Biolabs (NEB) invites applicants for Research Scientist I to join the DBTL team. You will bridge bench biochemistry with automated high-throughput engineering, guiding residue selection and assay design across enzyme families.

PhD level candidates with 1–2 years of relevant experience who can manage rapid experimentation, multitask under pressure, and communicate effectively across cores will thrive. Competitive base salary with strong benefits and ESOP options.

Qualifications

• Ph.D. in a scientific discipline with 1–2 years of academic or industry experience.
• Knowledge of protein structure–function relationships and mechanistic enzymology.
• Experience with directed evolution or protein engineering.
• Experience developing or miniaturizing plate-based assays; familiarity with liquid-handling automation is required.
• Ability to collaborate across labs and core facilities.
• Strong multitasking and attention to detail; rigorous notebook practices.
• Proven bench work quality and careful, consistent experiments.

Responsibilities

• Design enzyme chemistry and structure-guided residue selection and engineering strategy.
• Translate assays for enzyme families into high-throughput formats and optimize for automation.
• Establish high-throughput kinetic workflows and manage data generation and analysis.
• Advise on clone design and protein purification; coordinate with Cloning and Protein Purification Core.
• Validate hits from the Functional Screening Core and biochemically characterize promising candidates.
• Interpret results with the Bioinformatics Core and inform the next engineering cycle.

Skills

Protein structure-function

Directed evolution/Protein engineering

Plate-based assays/Automation

Across-lab collaboration

Lab notebook discipline

Multitasking under pressure

Education

Ph.D. in a scientific discipline

Tools

Liquid-handling automation

Job description

New England Biolabs (NEB) invites applicants for Research Scientist I to join the DBTL team. You will bridge bench biochemistry with automated high-throughput engineering, guiding residue selection and assay design across enzyme families.

PhD level candidates with 1–2 years of relevant experience who can manage rapid experimentation, multitask under pressure, and communicate effectively across cores will thrive. Competitive base salary with strong benefits and ESOP options.