Protein Engineering Research Scientist I

neb; Ipswich (MA); On-site; USD 80,000 - 90,000; Full time

Benefits offered by this job

Annual profit-sharing bonus

ESOP after two years

401k match

Comprehensive benefits

Job summary

New England Biolabs is seeking a Research Scientist I to bridge bench biochemistry with automated, high-throughput engineering within the DBTL framework. You will collaborate across cores to advance enzyme projects from design to testing.

Ideal candidates hold a PhD with 1–2 years of industrial or academic experience, strong knowledge of enzyme mechanisms, and hands-on experience in plate-based assays and liquid handling automation.

Qualifications

• PhD in a scientific discipline with relevant experience.
• Experience with protein structure-function relationships.
• Experience with directed evolution or protein engineering.
• Experience developing or miniaturizing plate-based assays; familiarity with liquid-handling automation.

Responsibilities

• Design enzyme chemistry-based residue selection and engineering strategy.
• Translate assays for enzyme families into high-throughput formats.
• Establish high-throughput kinetic workflows and manage data generation.
• Advise on clone design and protein purification with Core teams.
• Test and biochemically characterize promising hits; learn with Bioinformatics Core.

Skills

Protein engineering

Directed evolution

Plate-based assays

Automation

Education

PhD

Tools

Liquid handling automation

Job description

New England Biolabs is seeking a Research Scientist I to bridge bench biochemistry with automated, high-throughput engineering within the DBTL framework. You will collaborate across cores to advance enzyme projects from design to testing.

Ideal candidates hold a PhD with 1–2 years of industrial or academic experience, strong knowledge of enzyme mechanisms, and hands-on experience in plate-based assays and liquid handling automation.