Biocatalysis & Protein Engineering Scientist
Alnylam Pharmaceuticals
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Job summary
Alnylam Pharmaceuticals in Cambridge, MA is seeking a Scientist, Biocatalysis & Protein Engineering to discover and optimize biocatalysts for oligonucleotide and small-molecule manufacturing. The role will focus on directed evolution, molecular biology, and automated workflows to advance enzymes from discovery to process development.
You will collaborate across functions and with external partners to accelerate design, characterization, and transfer of catalysts into scalable manufacturing,
Qualifications
- PhD in Biochemistry, Molecular Biology, Protein Engineering, or related field; MS with industry experience; or BS with industry experience
- Experience in protein or enzyme engineering, directed evolution, or enzyme discovery
- Hands-on molecular biology techniques including cloning, mutagenesis, DNA assembly, and recombinant protein expression
- Experience developing and executing high-throughput screening assays and analyzing large datasets
- Strong knowledge of enzyme kinetics, structure-function relationships, and protein characterization
Responsibilities
- Design enzyme discovery and engineering campaigns to improve activity, stability, and selectivity
- Develop high-throughput screening assays to assess enzyme performance
- Collaborate with cross-functional teams and external partners to accelerate biocatalyst optimization
- Support transfer of engineered enzymes to scalable manufacturing processes
Skills
Education
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Job description
Alnylam Pharmaceuticals in Cambridge, MA is seeking a Scientist, Biocatalysis & Protein Engineering to discover and optimize biocatalysts for oligonucleotide and small-molecule manufacturing. The role will focus on directed evolution, molecular biology, and automated workflows to advance enzymes from discovery to process development.
You will collaborate across functions and with external partners to accelerate design, characterization, and transfer of catalysts into scalable manufacturing,
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