Principal Scientist - Small Molecule Process Development

Amgen; Cambridge (MA); Hybrid; USD 148,000 - 172,000; Full time

Job summary

Amgen invites applications for a Principal Scientist in Small Molecule Process Development. You will apply your expertise in synthetic organic chemistry to innovate manufacturing processes that significantly support drug development phases. Join us to make a lasting impact on patients’ lives while advancing your career in a collaborative biotech environment.

Benefits

Comprehensive employee benefits package

Retirement and Savings Plan

Flexible work models

Annual bonus program

Stock-based long-term incentives

Qualifications

• 7+ years scientific experience required with Bachelor's, 5+ years with Master's, or 2+ years with PhD.
• Experience in total synthesis, biocatalysis, or peptide chemistry preferred.
• Excellence in written and verbal communication skills essential.

Responsibilities

• Invent synthetic routes for drug substance manufacturing.
• Support cGMP manufacturing processes.
• Contribute to drug substance development teams.

Skills

Synthetic organic chemistry

Process development

Pharmaceutical development

Data interpretation

Technical writing

Education

Ph.D in organic chemistry or biochemistry

Master's degree

Bachelor’s degree

Job description

Career Category Operations Job Description Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Principal Scientist - Small Molecule Process Development

What you will do

Let’s do this. Let’s change the world. In this vital role you will apply your training in synthetic organic chemistry to the invention of chemical routes and processes that support drug substance manufacturing from early to late-stage development. The successful candidate will be a highly motivated individual with a strong background in organic chemistry and a proven track record of scientific innovation and achievement both as an independent contributor and in team settings.

• Invent synthetic routes and develop safe, robust, and cost-effective processes to manufacture synthetic and hybrid drug substances
• Advance enabling technologies to accelerate pharmaceutical development and to improve sustainability and process efficiency
• Support cGMP manufacturing and technology transfer to our internal manufacturing facilities and external contract manufacturers
• Ensure process performance through process understanding, modeling and characterization
• Contribute to and lead drug substance development teams by providing experimental results, technical updates, documentation, data interpretation, recommendations, etc.
• Work cross-functionally to deliver regulatory documents and support regulatory filings
• Serve as a technical expert and keep current in the field of organic and process chemistry
• Work effectively in a multi-disciplinary team of chemists, engineers and attribute scientists
• Independently develop experimental and testing plans to advance program objectives within required timelines.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The Scientific professional we seek is an individual with these qualifications.

Basic Qualifications:

• Bachelor’s degree and 7 years of Scientific experience; Or
• Master’s degree and 5 years of Scientific experience; Or
• Doctorate degree PhD OR PharmD OR MD and 2 years of Scientific experience

Preferred Qualifications:

• Ph.D. in organic chemistry and/or biochemistry with a specialization in total synthesis, reaction methodology, mechanistic studies, biocatalysis, peptide chemistry, oligonucleotide chemistry, and/or conjugation chemistry
• Post-doctoral experience in an academic laboratory or pharmaceutical/biotech industry
• Experience at a pharmaceutical/biotechnology company as a process development scientist
• Experience working with external contract development and manufacturing partners
• Track record of peer-reviewed publications and research presentations
• Demonstrated ability to work within a dynamic and interdisciplinary environment to achieve results
• Excellent written and verbal communication skills, ability to multitask, effectively plan and follow through on complex projects
• A research summary included with CV is strongly encouraged

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models, including remote and hybrid work arrangements, where possible

Apply now and make a lasting impact with the Amgen team. careers.amgen.com

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

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Salary Range

148,363.00 USD - 171,657.00 USD