Senior Principal Scientist - Large Scale Biology Leader

Novartis Farmacéutica; Cambridge (MA); On-site; USD 138,000 - 258,000; Full time

Job summary

A leading company seeks a Senior Principal Scientist to drive Large Scale Biology initiatives in Cambridge. The ideal candidate will have extensive experience in imaging technology and assay development, overseeing projects that contribute to innovative drug development. This strategic position involves collaboration with various departments, emphasizing advanced scientific approaches to reimagine medicine and improve lives.

Benefits

401(k) eligibility

Full range of medical benefits

Paid time off

Qualifications

• Strong track record in imaging technology and assay development.
• Experience in deploying imaging technologies at scale.
• Expertise in developing complex cell models and scaling assays.

Responsibilities

• Lead Large Scale Biology efforts in HTB Cambridge.
• Develop strategies to accelerate Target ID/Validation projects.
• Implement AI/machine learning for imaging data acquisition.

Skills

Imaging Technology

Assay Development

Complex Cell Models

Education

PhD with 6+ years or MS with 12+ years experience

Job description

Senior Principal Scientist - Large Scale Biology Leader

Job ID REQ-10049916

Apr 23, 2025

USA

Summary

We are seeking a highly skilled and experienced Senior Principal Scientist to lead our Large Scale Biology efforts in HTB Cambridge. The ideal candidate will have a strong background in imaging technology, assay development, and complex cell models. This role requires collaboration with various departments, including Discovery Sciences and other Biomedical Research Disease areas.

About the Role

Internal Job Title : Senior Principal Scientist

Location: Cambridge, MA, onsite

Job Summary:

We are seeking a highly skilled and experienced Senior Principal Scientist to lead our Large Scale Biology efforts in HTB Cambridge. The ideal candidate will have a strong background in imaging technology, assay development, and complex cell models. This role requires collaboration with various departments, including Discovery Sciences and other Biomedical Research Disease areas.

Key Responsibilities:

• Lead the Large Scale Biology efforts in HTB Cambridge, working with matrixed biology teams across Discovery Sciences and other Biomedical Research Disease areas.
• Develop and implement objectives for the Cambridge Large Scale Biology team to accelerate Target ID/Validation projects using complex biology models/assays through automation, automated cell-culture, imaging, and innovative bioengineering solutions.
• Build strong relationships with BR Bioengineering teams to innovate and iterate in collaboration with local project teams on novel solutions for large scale biology in Cambridge.
• Lead efforts to build and foster a local imaging community in Cambridge, reviewing imaging project designs and implementations across Discovery Sciences.
• Implement Discovery Sciences AI/machine learning strategies in Cambridge for imaging data acquisition and analysis, aligned with the global strategy.
• Scout for innovative solutions to scaling biology and prototype these through collaborations or pilot evaluations with biology teams in Discovery Sciences or Disease Areas in Cambridge.
• Contribute to the career development of associates and maintain the culture of HTB Cambridge as a member of the Discovery Sciences HTB Cambridge Leadership Team.

Qualifications:

• PhD with 6+ years or MS with 12+ years of experience in industry, with a strong track record in imaging technology and assay development applied to complex cell assays and models.
• Strong expertise in deploying imaging technologies at scale as applied to genetic and/or small molecule screening.
• Expertise in complex cell model development with an emphasis on automating and scaling assays for robustness and increased throughput.
• Strong knowledge of assay development with a concentration on complex cell-based biology readouts (2D/3D cell models/assays) combined with automation solutions for biology at scale.

Why Novartis : Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture

Novartis Compensation and Benefit Summary : The pay range for this position at commencement of employment is expected to be between $138,600 to $257,400/year; however, while salary ranges are effective from 1/1/25 through 12/31/25, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills, and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Join our Novartis Network : If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network

Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture

Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network

The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.

Accessibility & Reasonable Accommodations

The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to [e-mail] or call [phone] and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Division Biomedical Research

Business Unit Pharma Research

Location USA

State Massachusetts

Site Cambridge (USA)

Company / Legal Entity U175 (FCRS = US175) Novartis Institutes for BioMedical Research, Inc.