Principal Scientist (Research Scientist)

ICON; Lenexa (KS); On-site; USD 110,000 - 170,000; Full time

Benefits offered by this job

Health insurance

Retirement planning

Employee assistance program

Job summary

ICON is seeking a Principal Scientist (Research Scientist) in Lenexa, Kansas to lead method development using LC/MS/MS for preclinical and clinical specimens. You will guide assay strategies, review data, and ensure robust transfers across ICON labs.

The role emphasizes leadership in bioanalytical science, collaboration across departments, and engagement with sponsor programs to advance clinical trials and novel modalities.

Qualifications

• PhD or equivalent in a relevant field such as biology, chemistry, pharmacology or clinical research.
• MS degrees considered with proven LC/MS/MS method development experience.
• Experience with radiolabeled analytes and biologics such as proteins, peptides, ADCs, oligonucleotides, mAbs.

Responsibilities

• Direct development and validation of LC/MS/MS assays for preclinical and clinical specimens.
• Oversee transfer of robust LC/MS/MS methods for biologics testing.
• Review data presentations for sponsors and provide data-focused insights.
• Support Laboratory Operations with assay quality and troubleshooting.
• Drive client discussions on assay requirements and contribute to publications.

Skills

Bioanalytical method development

Data interpretation

Scientific communication

Travel readiness

Education

PhD or equivalent in biology/chemistry

MS with LC/MS/MS experience

Tools

Tomtec

Hamilton

Kingfisher

Integra Assist Plus

Job description

Principal Scientist (Research Scientist)- Bioanalytical, LC/MS/MS) - Full time, Salary, Benefits - Lenexa, Kansas (KS)

ICON is a global healthcare intelligence and clinical research organisation united by a mission to bring new medicines and treatments to patients faster.

As a values-driven organisation, integrity, collaboration, agility, and inclusion are at the heart of how we work and interact with each other, customers, patients and suppliers.

Are you a scientist with expertise in method development? Take the next step in your career by joining ICON where you’ll advance groundbreaking clinical therapies by leading global client programs.

We are excited to be seeking a new Principal Scientist (Research Scientist) at ICON in Lenexa, Kansas (KS). The Principal Scientist (Research Scientist) will lead and conduct scientific research aimed at advancing clinical trials and developing innovative therapies. You will manage sponsor programs, shape assay strategies, and provide expertise for new and complex modalities.

We are seeking candidates with strong bioanalytical method development experience and expertise in emerging biological modalities.

What You Will Do:

The Principal Scientist (Research Scientist) is responsible for method development and validation for testing preclinical and clinical specimens using LC/MS/MS analytical methods. In addition, you will oversee transfer robust LC/MS/MS methods for biologics for bioanalytical testing. Key responsibilities include:

• Independently direct development and validation of new LC/MS/MS assays using appropriate methods such as (but not limited to) Tomtec, Hamilton, Kingfisher, Integra Assist plus, etc.
• Ensure robust LC/MS/MS methods are developed for successful method validation of both small molecules, radiolabeled analytes and biologics such as proteins, peptides, ADCs, oligonucleotides, monoclonal antibodies (mAb), etc.
• Review data presentations for accuracy and clarity prior to sharing with sponsors
• Provide support to Laboratory Operations staff regarding assay quality, expected results, troubleshooting and data review
• Provide technical input for ICON Marketing collateral, attend conferences, publish papers in the peer-reviewed literature
• Drive new business by consulting with sponsors on assay requirements for new projects
• Collaborate with inter-departmental functions to write and review validation plans, reports and SOP’s
• Lead assay transfers to other ICON lab locations

Your Profile:

Required qualifications and experience:

• PhD or equivalent degree in a relevant scientific field such as biology, chemistry, pharmacology, or clinical research.
• MS degrees considered with proven LC/MS/MS method development experience in the pharmaceutical or clinical research industry.
• Experience with some or all of the following: radiolabeled analytes and biologics such as proteins, peptides, ADCs, oligonucleotides, monoclonal antibodies (mAb), etc.
• Experience in conducting research within the clinical or pharmaceutical industry, with a proven track record of managing scientific projects.
• Strong analytical skills and expertise in data interpretation and statistical analysis.
• Excellent written and verbal communication skills, with the ability to present complex scientific information to both technical and non-technical audiences.
• Willingness to travel as required (approximately 5%)

What ICON can offer you:

Our success depends on the quality of our people. That’s why we’ve made it a priority to build a diverse culture that rewards high performance and nurtures talent.

In addition to your competitive salary, ICON offers a range of additional benefits. Our benefits are designed to be competitive within each country and are focused on well-being and work life balance opportunities for you and your family.

Our benefits examples include:

• Various annual leave entitlements
• A range of health insurance offerings to suit you and your family’s needs.
• Competitive retirement planning offerings to maximize savings and plan with confidence for the years ahead.
• Global Employee Assistance Programme, LifeWorks, offering 24-hour access to a global network of over 80,000 independent specialized professionals who are there to support you and your family’s well-being.
• Life assurance
• Flexible country-specific optional benefits, including childcare vouchers, bike purchase schemes, discounted gym memberships, subsidized travel passes, health assessments, among others.

Visit our careers site to read more about the benefits ICON offers.

At ICON, inclusion & belonging are fundamental to our culture and values. We’re dedicated to providing an inclusive and accessible environment for all candidates. ICON is committed to providing a workplace free of discrimination and harassment. All qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please let us know or submit a request here

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