Principal Scientist - Protein Purification Team Lead

Scorpion Therapeutics

Spring House (PA)

On-site

USD 150,000 - 210,000

Full time

6 days ago

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Job summary

Johnson & Johnson's Biologics Discovery seeks a Principal Scientist and Team Lead in Protein Purification. The role focuses on advancing therapeutic antibodies, multispecifics, and recombinant proteins for preclinical studies.

You will lead a team, define purification strategies, guide process development and scaling, and optimize quality and yield using chromatography, FPLC, HPLC, and analytical methods. Cross-functional collaboration is essential.

Qualifications

PhD in biochemistry, biochemical or chemical engineering or related field.
5+ years in biologics or drug discovery within pharma or biotech.
Proven leadership in scientific team development.
Deep expertise in protein purification and characterization.
Experience with scalable process transfer.

Responsibilities

Build and lead a team of scientists.
Define purification strategies for biologics projects.
Guide process development and scaling for protein production.
Apply chromatography, FPLC, and HPLC along with analytical methods to optimize quality, yield, and scalability.
Collaborate across discovery, development, and enabling functions.
Influence decisions on molecule quality and characterization.
Improve automation and digital workflows across the purification platform.