Principal Scientist - Obesity & Cardiometabolic Therapeutics

Amgen SA

Thousand Oaks (CA)

Sur place

USD 170 000 - 210 000

Plein temps

14 jours+

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Résumé du poste

Amgen in Thousand Oaks seeks a Principal Scientist to lead discovery and preclinical development for obesity and cardiometabolic diseases. You will design translational pharmacology strategies and guide candidate selection across multiple programs, collaborating with biology, pharmacokinetics, and clinical development teams.

The role requires a PhD or equivalent with 5+ years in drug discovery, deep GPCR biology expertise, and strong leadership and collaboration skills.

Qualifications

PhD in Pharmacology or related field with 5+ years in drug discovery.
Experience leading cross-functional discovery programs.
Strong publication and collaboration track record.

Responsabilités

Provide scientific leadership for obesity drug discovery programs from target identification through candidate selection.
Develop translational pharmacology strategies to evaluate novel mechanisms and optimize candidates.
Design, oversee, and interpret in vitro/in vivo pharmacology studies (PK/PD, efficacy, mechanism of action).
Lead cross-functional scientific discussions and influence program direction with data-driven decisions.
Mentor scientists and foster collaboration across biology, pharmacokinetics, toxicology, biomarker sciences, and clinical development.
Present findings to project teams, senior leadership, and external audiences.
Contribute to publications, presentations, and scientific strategy for obesity research portfolio.